This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $528,129 to the University of Connecticut Health Center (UCHC) to conduct research on the ubiquitin-proteasome pathway and its role in human disease.
The research program aims to structurally and functionally characterize critical ubiquitinating and de-ubiquitinating enzymes, with a focus on the deubiquitinating enzyme USP7. The award will support projects to investigate the regulation of USP7 activity through conformational dynamics, analyze the structural complex between USP7 and its substrate MAGE-L2, and identify major cellular pathways affected by USP7 malfunction. The anticipated results are expected to elucidate fundamental molecular mechanisms of this clinically relevant deubiquitinating enzyme, which could guide future efforts to develop new therapeutic strategies for diseases associated with ubiquitin-proteasome pathway dysfunction.
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