This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) funds research to expand understanding of the biosynthetic capabilities of filamentous fungi. The $495,117 grant, awarded on January 1, 2025 with a completion date of December 31, 2029, focuses on three key areas:
- Elucidating the products of fungal isocyanide biosynthetic gene clusters, including those with unique enzymatic features or chemistries.
- Examining how isocyanide natural products influence microbiome composition based on metal concentrations.
- Leveraging computational approaches to advance the discovery of new fungal natural products.
The research aims to promote the understanding of the chemistry and ecology of the poorly characterized isocyanide natural products, as well as align molecular, chemical, and computational methods to uncover new natural product classes from fungi. The findings are expected to provide critical knowledge to address challenges in human health worldwide.
Generated 3/4/25, 7:53 AM