This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $410,000.00 in funding to The Trustees of Princeton University over a 5-year period from September 1, 2024 to June 30, 2029. The goal of this research project is to uncover the molecular determinants that control the stability, composition, and assembly mechanisms of intracellular biomolecular condensates - liquid-liquid...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $410,000.00 to The Trustees of Princeton University to conduct research aimed at bridging the understanding between molecular structure and the material properties of biomolecular condensates, such as stress granules. The goal is to develop accurate computational models to characterize the molecular interactions within these...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the regulation of RNA condensates, also known as membraneless organelles or RNA granules, by RNA helicases in biological development. The $375,430 award, effective February 1, 2025 through December 31, 2029, will be utilized by the University of Wisconsin - Madison to combine analysis...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS Biomedical Research and Research Training program, CFDA 93.859) provides $179,736.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on the post-translational regulation of NORAD-induced Pumilio phase separation in biomolecular condensates. The key objectives are to: 1) quantify the dispersal of NORAD-Pumilio (NP) bodies during mitosis and their reassembly in G1...
This federal Project Grant award of $1,245,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will establish a high-throughput, generalizable quantitative structural cell biology platform to study dense core secretory granule (DCSG) maturation. The award, which runs from July 1, 2024 to April 30, 2029, will leverage soft X-ray tomography (SXT) and fluorescence lifetime imaging microscopy (FLIM) to map cell...
The National Institute of General Medical Sciences (NIGMS) awarded a $452,250 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Pittsburgh from June 1, 2025 to April 30, 2030. The grant aims to develop innovative tools to understand how nuclear speckles, a type of cellular structure, detect proteostatic stress and regulate protein quality control mechanisms. This research seeks to elucidate the central regulatory mechanisms governing the...
The National Institute of General Medical Sciences (NIGMS) has awarded a $747,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Vanderbilt University. The purpose of this 3-year grant, effective July 1, 2024, is to investigate the mechanisms by which the ribosome quality control (RQC) pathway and integrated stress response (ISR) detect and respond to ribosome collisions on mRNAs, and to examine the role of disome regulation in neuronal differentiation...
This Project Grant award for $778,444 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to understand the structure and function of phospholipids and inositol phosphates within the cell nucleus. The research team at Vanderbilt University Medical Center will use chemical biology approaches to investigate the roles of these nuclear lipid signaling molecules, with the goal of uncovering new...
This $462,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to develop chemical modulators of RNA-protein assemblies through the targeting of DEAD-box RNA-dependent ATPases. The research aims to generate selective inhibitors that can allosterically regulate RNA affinity, with the goal of propelling biological studies of RNA-protein complexes and potentially leading to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports advanced microscopy techniques to study the spatial organization and dynamics of cellular components. The $852,726 award will fund research to elucidate how molecular assemblies regulate organelle transport and positioning, how organelle identity links to positioning and function, and the relationship between chromatin...