The National Institute of General Medical Sciences (NIGMS) has awarded a $411,250 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division, for a 5-year project titled "Mechanisms and Genetic Consequences of Break-Induced Replication." The project aims to study the mechanisms and genetic consequences of break-induced replication (BIR), a unique DNA repair process that can lead to genome instability. The research will take a multidisciplinary approach combining cell biology, biochemistry, and genomics to (1) determine how BIR is regulated at telomeres and transcriptionally active loci, and (2) develop new experimental tools and techniques for studying BIR. This work is expected to elucidate the connection between BIR, genome instability, and telomere elongation, as well as identify upstream regulatory mechanisms that initiate BIR coupled with transcription. The grant award period spans from September 1, 2024 to June 30, 2029.
Generated 2/25/25, 4:33 AM