This $385,700 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research at the University of Pittsburgh over a 5-year period from September 2024 to August 2029. The research aims to develop advanced computational and machine learning models that integrate diverse biomedical data, from genetics to transcriptomics and proteomics, to better predict the effects of therapies on diseased cells....
This National Science Foundation (NSF) Project Grant award under the Mathematical and Physical Sciences program (CFDA 47.049) provides $250,000 to The Trustees of the University of Pennsylvania to develop advanced statistical methods for integrating and analyzing large-scale data from multiple sources, such as electronic health records and genomics data. The project aims to devise new data-driven algorithms with theoretical optimality guarantees for transfer learning, as well as adversarially...
This $767,525 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to harness the potential of radical-mediated migrations to develop new synthetic transformations for pharmaceutical development. The grant supports research by The Pennsylvania State University to make significant advances in olefin difunctionalizations and stereoselective α-functionalizations of carbonyls. These...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research to develop novel computational methods for integrating large-scale genomic datasets to better understand the regulatory networks underlying complex human traits and diseases. The $533,801.84 award, effective September 18, 2024 through June 30, 2027, will enable the awardee, The Trustees of the University of Pennsylvania, to: 1) improve causal structure learning...
The National Institute of General Medical Sciences (NIGMS) awarded a $752,456 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant, effective September 1, 2024 through July 31, 2029, supports the development and application of innovative, user-friendly computational technologies for identifying new bioactive small molecules and improving their pharmacological properties. Key focus areas include creating a database of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is providing $1,043,301 to The Leland Stanford Junior University to develop computational methods for characterizing sources of variability in drug response. The project aims to generate a more complete understanding of drug response mechanisms and their underlying sources of variation, in order to enable more precise drug therapies....
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 - Biomedical Research and Research Training provides $278,104 to the University of Texas at Arlington to develop novel machine learning-based predictive models for early disease detection and treatment strategies. The key objectives are to: (I) create biologically motivated ML models that can accurately predict whether patients are cured or uncured of their disease; (II) develop...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,218,750 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The grant, with a period of performance from Sep 1, 2024 to Jun 30, 2029, will fund the development of new biomaterial platforms and bioorthogonal chemistries to study cellular mechanosensing and...
The National Institute of General Medical Sciences (NIGMS) awarded a $148,880 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Pennsylvania State University (Penn State) on December 1, 2024. The funding will support research to elucidate the role of metal cofactors in the GDGT-MAS enzyme, which facilitates the formation of carbon-carbon bonds from inert carbons - a rare biological capability. The research aims to characterize the spectroscopic and...
This Project Grant award of $828,814, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Pennsylvania State University focused on harnessing the power of k-mers - short nucleic or peptide sequences - to advance genomic and proteomic research. The key products and services to be delivered include: Examining quasi-prime k-mers, which are found in only one species, across diverse...