This $1,286,156 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research by The Trustees of the University of Pennsylvania to advance the understanding of cytokinesis and the septin cytoskeleton. The research aims to address key questions regarding the architecture and constriction mechanism of the actomyosin ring, the mechanism of vesicle fusion at the cell division site, and the assembly and remodeling of high-order septin structures. The work will use the budding yeast model system, supplemented by investigations in fission yeast and mammalian cells, and will leverage advanced imaging and structural prediction techniques. The project is expected to generate deep insights into the fundamental cellular processes of cytokinesis and septin dynamics, which are critically important for basic biology and public health given their connection to various diseases.
Generated 3/25/25, 5:20 AM