The University of Chicago received a $806,224 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) with a start date of July 19, 2024 and an ultimate completion date of May 31, 2029. The overarching goal of this project is to understand how RNA splicing is encoded in DNA sequence and how it impacts biological function, with the aim of leveraging this knowledge to help design treatments or drugs to improve human health. To achieve these goals, the project proposes to: (1) develop computational methods to facilitate studies of RNA splicing in human biology and disease, (2) characterize splicing-mediated regulation of gene expression levels, and (3) investigate mechanisms of RNA splicing modulation by small molecules. This research has the potential to significantly advance the understanding of RNA splicing mechanisms and function, and help establish mRNA splicing as a target for future therapies.
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