This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $393,149 in funding to Brandeis University for a 5-year period from June 1, 2025 to March 31, 2030. The overarching goal of the research is to address key gaps in understanding how protein phosphatases, specifically the PPM family of serine/threonine phosphatases, are regulated and directed to their substrate proteins. The...
This federal Project Grant award of $452,192 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of pan- and phospho-specific nanobodies for investigating MAPK and PP2A signaling at Vanderbilt University. The goal of this 4-year research project, commencing on June 1, 2025, is to advance the understanding of the reversible protein phosphorylation processes that control cellular homeostasis. The...
This federal Project Grant award for $1,323,912, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Temple University to fully delineate the molecular mechanisms by which the protein phosphatase 2A (PP2A) holoenzyme, specifically PP2A/B55A, recognizes its substrates through a new helical motif. The goal is to use this information to identify direct PP2A/B55A substrates with...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $839,700.00 in funding to the University of Washington from August 10, 2024 to July 31, 2029. The research project aims to investigate how protein phosphorylation regulates the organization of the cellular proteome. Specifically, the researchers will: 1) identify phosphorylation sites relevant to protein function at...
This $380,540 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to decipher new principles of rapid proteostatic control and develop spatiotemporal lysosomal tools. The key research activities include: 1) defining novel protein substrates and motifs required for lysosomal delivery, 2) determining the functional impact of methyl-driven lysosomal proteolysis on...
This $300,892 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the biosynthesis and identify novel dehydrated nonribosomal peptides produced by Streptomyces bacteria. The project aims to characterize the enzymes and biosynthetic pathways involved in the production of these natural products, which have potential therapeutic applications due to their...
This $379,823 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, Irvine. The award supports research to define the mechanisms driving novel cyclic nucleotide signaling pathways involved in immune defense, with a focus on examining the evolutionary relationships between cyclic nucleotide-based immune defense systems in prokaryotes and...
This $444,262 project grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of innovative reagents and methods for the synthesis of oligophosphate constructs. The key products and services to be delivered include: New reagents and methods for synthesizing oligophosphate chains up to pentaphosphorylation and beyond, including those with non-hydrolyzable P-C bonds. These...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $360,100 to fund research aimed at elucidating biological mechanisms for proton transfer. The project will leverage computational protein design tools to create designer proteins that bind photoacid cofactors, enabling spectroscopic observation of proton dynamics in an isolated, experimentally tractable system. This...
The Department of Health and Human Services' National Institute of General Medical Sciences awarded Oregon Health & Science University a $2,680,200 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 1, 2022 through August 31, 2025. The grant will support research to elucidate signaling pathways of the P2X7 purinergic receptor and develop novel small molecule and aptamer ligand therapies. Specifically, the recipient will utilize...