The National Institute of General Medical Sciences (NIGMS) awarded a $1,084,158 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Regents of the University of Michigan (University of Michigan) to develop and utilize chemical biology approaches for investigating RNA-protein interactions. The research aims to: 1) continue development of the University's live-cell RNA interaction with protein-mediated complementation assay (RIPCA) platform for validating and manipulating cellular RNA-protein interactions, 2) use RIPCA to expand access to chemical probes for targeting cellular RNA-protein interactions, and 3) leverage mechanistically distinct chemical probes targeting EIF4E to explore the context-dependence of RNA-binding protein regulation and activity. This 5-year project, commencing September 1, 2024, is expected to promote understanding of this new frontier of cellular biology with potential for developing new medicines.
Generated 3/4/25, 7:48 AM