This $774,978 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research at The Ohio State University to investigate the role of the O-GlcNAc transferase (OGT) enzyme in host defense mechanisms against viral and bacterial pathogens.
The project aims to elucidate how OGT senses pathogen infection and integrates innate immune responses and cellular metabolism, as well as the functional importance of OGT-mediated protein O-GlcNAcylation in intracellular bacterial detection. The research will leverage newly developed OGT enzyme-inactive and gene-deletion mouse models to advance the understanding of OGT's central role in the host defense system. The findings are expected to significantly advance the field of immunometabolism by elucidating how this metabolic enzyme regulates immune responses to pathogens. The award has a period of performance from September 2024 through June 2029.
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