This $391,250 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to uncover the mechanistic basis for how chromatin modifications recruit and activate the gene silencing enzymes Polycomb Repressive Complex 1 (PRC1), Polycomb Repressive Complex 2 (PRC2), and DNA Methyltransferase 1 (DNMT1). The awardee, The Regents of the University of Colorado (CU), will utilize an...
The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $667,480 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to St. Jude Children's Research Hospital Inc. to conduct structural and functional studies of chromatin dynamics. The project aims to understand how chromatin structure and modifications regulate gene expression, DNA replication, repair, and cellular processes, with a focus on the biology of repetitive genomic elements and the mechanisms of...
This $427,571 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to uncover the molecular determinants of cellular identity and the role of chromatin dynamics in regulating gene expression across the cell cycle. The key products and services to be delivered include: Developing new time-resolved structural epigenomic approaches to identify chromatin states that cannot...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop an ultra-high-throughput platform called PRANCS for structure-function analysis of histone reader proteins and their mutations. The $148,880 award, covering the period from December 1, 2024 to November 30, 2026, will fund the following key products and services: Improved robotics methods to parallelize the PRANCS platform...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,271,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Weill Medical College of Cornell University. The grant, effective August 1, 2024 through May 31, 2029, supports research to investigate the spatiotemporal regulation of epigenetic silencing by macromolecular interactions. The research aims to elucidate the mechanism by which the "writer" enzyme Polycomb Repressive...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to investigate the effects of polyamines on chromatin function and their impact on cell fate and chromatin homeostasis. The 5-year, $411,250 award to The Trustees of Columbia University in the City of New York will enable the principal investigator to explore how changes in intracellular and extracellular polyamines...
This federal Project Grant award, valued at $254,919.00 and awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to understand the regulatory mechanisms that ensure accurate transmission of the genome during cell division. The overarching goal of the research is to investigate two key areas: 1) how post-translational modification enzymes regulate the assembly and function of DNA...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 (Biomedical Research and Research Training), provides $597,573 to The Ohio State University to conduct structural and dynamic studies of large protein and protein-nucleic acid complexes and assemblies. The research aims to provide atomic-level insights into the structure, dynamics, interactions, and function of nucleosomes, chromatin, and prion protein amyloids, which...
This federal Project Grant award for $275,581, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports a research program at Colorado State University (CSU) to study the mechanisms and functions of three-dimensional chromatin structures in quiescent cells. The key objectives of this five-year research project are to: 1) uncover how the chromatin structural complex condensin relocates and forms loop...
This $148,568 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program will support research to elucidate the role of chromatin structures in genomic imprinting. The project, led by Harvard University, aims to investigate the regulatory mechanisms and functional implications of allele-specific chromatin structures in the regulation of the MEST-COPG2 imprinted domain, which is associated with...
This $1,545,538 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 (Biomedical Research and Research Training) will support research by the University of Georgia Research Foundation to study the composition, assembly, and function of specialized chromatin domains, with a focus on Polycomb Group (PCG) proteins and the Polycomb Repressive Complex 2 (PRC2). The research aims to uncover the mechanisms controlling the establishment, spreading, and epigenetic inheritance of the histone modification H3K27me3, as well as the role of the ISWI chromatin remodeling enzyme in PCG-repressed chromatin domains. Additionally, the project will investigate how H3K27me3 levels are re-established following DNA replication and identify other factors that control PCG-repressed chromatin. Successful completion of these research aims is expected to reveal general principles and mechanisms governing the assembly and function of PCG-repressed chromatin domains, which have implications for understanding and treating human diseases such as cancer that are linked to dysregulation of these chromatin regulators.