Project Grant R34HL184529
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $292,500 Project Grant to Sanford Burnham Prebys Medical Discovery Institute effective August 15, 2025, through July 31, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). This interdisciplinary research project aims to identify and characterize novel microproteins encoded by small open reading frames (SMORFs) that play critical roles in normal hematopoiesis and hematopoietic...
- Federal Project Grant Award Summary The University of Minnesota received a $1.57 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 1, 2026, with completion by February 29, 2028. The award funds mechanistic research into chronic graft-versus-host disease (CGVHD) pathobiology and the development of novel anti-fibrotic therapies. Using state-of-the-art murine models and advanced molecular...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $811,885 to the J. David Gladstone Institutes under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025. The award funds research to elucidate epigenomic mechanisms of cardiac fibrosis and heart failure pathogenesis, with a completion date of May 31, 2029. The research leverages novel genetic mouse models, advanced transcriptional and epigenomic...
- Federal Project Grant Award Summary Dr. Sarah Heston's Mentored Patient-Oriented Research Career Development Award (K23) from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $163,923 in obligated funding over a five-year period (August 1, 2025 – July 31, 2030) to support research investigating the role of the gut microbiome in acute gastrointestinal graft-versus-host disease (GI-GVHD) following allogeneic...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Feinstein Institutes for Medical Research a Project Grant of $586,866 under the Cardiovascular Diseases Research program (CFDA 93.837) on May 15, 2026, with a completion date of February 28, 2030. This award funds research investigating the critical role of B-1A cells, an immunoregulatory B cell subset, in mitigating acute lung injury (ALI) and acute respiratory distress...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $1,072,936 to the University of California, San Diego, effective September 15, 2025, through June 30, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports fundamental research investigating protein aggregation mechanisms in hematopoietic stem cells (HSCs), with the primary deliverable being scientific research and discovery designed to advance...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a $5.96 million Project Grant on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a multi-omic investigation optimizing hematopoietic stem cell transplantation (HCT) outcomes. The five-year research initiative, scheduled for completion by May 31, 2030, will deliver mechanistic and translational science research aimed at improving...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $521,101 Project Grant to the University of Wisconsin–Madison, with an award date of June 15, 2026, and completion date of February 28, 2031, under the Cardiovascular Diseases Research program (CFDA 93.837). The research focuses on defining the mechanisms by which hematopoietic stem cells (HSCs) acquire macrophage-associated markers through trogocytosis—a cellular membrane transfer mechanism—and...
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $151,092 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through July 31, 2030. This five-year research initiative focuses on investigating macrophage polarization and function in graft-versus-host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of California, Los Angeles a $1.56 million Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective July 15, 2026, with completion targeted for March 31, 2028. This award funds basic science research to elucidate the role of noncoding RNA—specifically long noncoding RNAs (lncRNAs) and micropeptides—in cardiovascular disease pathogenesis, with emphasis on lipid metabolism,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded Sloan-Kettering Institute for Cancer Research a $281,722 Project Grant effective July 15, 2026, through June 30, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). This award funds development and evaluation of a rationally designed oral live biotherapeutic product (LBP) intended to treat gastrointestinal acute graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic cell transplantation. The LBP will deliver a defined composition of pure bacterial strains to modulate the gastrointestinal microbiome, offering advantages over existing fecal microbiota transplantation (FMT) approaches by eliminating batch-to-batch variability and reducing risks of infectious organism or antibiotic-resistance gene transmission while potentially avoiding the immunosuppressive effects of current standard therapies. The research addresses a critical clinical need, as GVHD remains a major driver of mortality following allogeneic hematopoietic cell transplantation, with limited treatment options beyond current immunosuppressive approaches and the FDA-approved ruxolitinib, which frequently shows partial improvement with short-term response duration. This microbiome-based therapeutic approach represents a novel strategy to treat gastrointestinal GVHD without compromising the intended anti-tumor activity of the transplanted immune cells.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $281.7k | 7/8/26 |