The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $264,596 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Trustees of the University of Pennsylvania (Penn), doing business as Clinical Practices of the University of Pennsylvania. The grant will fund a prospective randomized study to assess whether serum microRNA (miRNA) profiling can assist in safely tapering immunosuppression for liver transplant recipients compared to clinically guided management. The research aims to develop miRNA biomarker profiles that can detect early immune response activation and allograft injury, enabling personalized immunosuppression management and reducing the risk of rejection. The study will also leverage a novel methylation-based technology to interrogate liver pathology and immune/inflammatory cell activation associated with immunosuppression tapering. The award runs from August 2024 through July 2025.
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