Project Grant R33CA309701
- Federal Project Grant Award Summary The University of Chicago received a $372,628 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) effective September 12, 2025, with completion targeted for August 31, 2028. This award supports research into spatiomolecular profiling of human cancer at scale, specifically focused on developing and advancing spatially resolved transcriptomics (ST) technologies for analyzing tumor...
- Federal Grant Award Summary The University of Chicago received a $518,151 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective July 1, 2026 through June 30, 2031. This award supports research to advance Nicotinamide N-Methyltransferase (NNMT) inhibition as a therapeutic strategy to enhance cancer immunotherapy responsiveness. The project focuses on developing NNMTI'960, a small-molecule NNMT inhibitor, toward Investigational...
- Federal Project Grant Award Summary The University of Chicago received a $547,740 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) effective July 1, 2026, through June 30, 2031. The award funds research to define the molecular mechanisms underlying RNA binding by the MLL1 (KMT2A) histone modification complex and its role in acute myeloid leukemia. Specifically, the research investigates how the long noncoding RNA HOTTIP...
- Federal Grant Award Summary The University of Chicago received a $391,951 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. The award funds fundamental research to probe and target lysyl oxidase (LOX) enzymes and their role in cancer pathophysiology. The research focuses on understanding how protein post-translational modifications...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Project Grant Award Summary The University of Chicago received a $602,641 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), awarded on June 24, 2026, with a completion date of May 31, 2031. This grant supports research on immune checkpoint inhibitors (CPIs) and their associated adverse effects, specifically immune-related adverse events (IRAEs) that manifest as cutaneous lichenoid rashes and colitis in cancer patients undergoing CPI...
- Federal Grant Award Summary The University of Chicago received a $249,000 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), effective April 1, 2026, through March 31, 2029. This award funds the development of explainable artificial intelligence (AI) models to predict melanoma recurrence in early-stage (Stage I/II) patients. The research integrates multiplexed tissue imaging, spatial transcriptomics, and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Chicago a $588,289 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026 through April 30, 2031. The award funds fundamental research to mechanistically characterize how BH3 (BCL-2 homology domain 3) mimetic therapeutics alter human T cell function through BCL-2 family protein-protein interactions. The project investigates non-apoptotic immunomodulatory...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $402,135 by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on May 1, 2026, for a three-year project extending through April 30, 2029. The award funds development of SCHICAR (Single-Cell Histone-level Chromatin Interaction and Accessibility with RNA), a novel tri-modal single-cell platform designed to simultaneously capture high-resolution three-dimensional...
- Federal Grant Award Summary The National Cancer Institute (NCI), under the Cancer Biology Research program (CFDA 93.396), awarded a $668,362 Project Grant to The Regents of the University of California, San Francisco on July 7, 2026, with a completion date of June 30, 2031. This five-year award supports fundamental cancer biology research focused on decoding ribosomal RNA (rRNA) modifications and their role in cancer development and progression. The research will investigate how cancer cells...
The University of Chicago received a $388,234 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2026, through July 31, 2029. This award funds the development and application of SNORNA-Enriched Kethoxal-Assisted RNA-RNA Sequencing (SNOKARR-SEQ), an advanced sequencing technology designed to identify small nucleolar RNA (snoRNA) targets at transcriptome-wide scale. The project addresses a critical gap in cancer biology research by enabling comprehensive mapping of snoRNA-target interactions, which have previously been under-appreciated in understanding tumor initiation, progression, and metastasis. The award supports two primary objectives: (1) enhancing the sensitivity and resolution of SNOKARR-SEQ through mutation profiling and snoRNA-specific priming and amplification strategies to identify low-abundance snoRNA targets in cancer cells, and (2) constructing a comprehensive pan-cancer atlas of snoRNA targets across multiple cancer cell types to establish a foundational resource for basic and clinical cancer research. The resulting datasets and technological advances are intended to provide unprecedented information for determining how snoRNA-target interactions can be manipulated for cancer treatment and diagnosis applications.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $388.2k | 7/17/26 |