Project Grant R33CA126966

Grant Award Summary Avant Genomics, Inc. received a $305,000 Small Business Innovation Research (SBIR) Phase I project grant from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) to develop an automated system for liquid biopsy sample preparation. The company will design and optimize a microfluidic-based instrument with a disposable cartridge that automates bisulfite conversion, a critical but labor-intensive step in preparing circulating...

The National Human Genome Research Institute (NHGRI) awarded Dana-Farber Cancer Institute, Inc. a Project Grant totaling $501,618 under the Human Genome Research program (CFDA 93.172) effective September 1, 2025, through June 30, 2029. This grant supports the development of advanced computational tools for variant calling from long genomic and RNA sequencing reads. The primary deliverables include: (1) a novel variant caller for identifying germline variants, mosaic mutations, and RNA editing...

The U.S. National Human Genome Research Institute (NHGRI) awarded a $1,696,968 Cooperative Agreement grant (CFDA 93.172 - Human Genome Research) to the University of California, Santa Cruz to develop novel computational methods and software tools for analyzing pangenomic data, with a focus on improving the accuracy and efficiency of variant calling and genotyping, particularly for complex structural variants. The grant, titled "Tools for Comprehensive Variant Characterization Using the...

The National Human Genome Research Institute (NHGRI) awarded a $339,000 Project Grant (CFDA 93.172 - Human Genome Research) to Rockefeller University to develop GFASTAR, a C++ library and tool suite to aid telomere-to-telomere (T2T) genome assembly. The project aims to advance algorithms and software tools for evaluating and manipulating genome assembly graphs, which are essential for generating high-quality, complete, and accurate T2T reference genomes across multiple species. The GFASTAR...

Federal Grant Award Summary Electronic Biosciences, Inc. received a Phase I Small Business Innovation Research (SBIR) Project Grant of $383,482 from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded June 6, 2025, with completion targeted for May 31, 2027. The award supports development of SPINSEQ, an innovative RNA sequencing platform designed to deliver high-precision transcriptomic analysis while preserving RNA modifications...

The Alida Biosciences Inc. was awarded a $765,105 Project Grant from the National Institutes of Health National Human Genome Research Institute under the Human Genome Research federal grant program (CFDA 93.172) on August 17, 2021 to complete work by February 28, 2022. The grant funds the development of a new approach to analyze RNA modifications across entire transcriptomes in a multiplexed reaction at near single-base resolution. Currently available methods either lack sequence context or...

The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...

Castag Biosciences, Inc. received a $255,730 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041). The award, issued on February 15, 2021 with a completion date of January 31, 2022, will support SBIR PHASE I: HIUGE POWERED CRISPR KNOCK-IN LIBRARY FOR PROTEIN TAGGING ACROSS THE HUMAN GENOME. Specifically, the funding will enable Castag Biosciences to develop a CRISPR-based library and workflow to...

Triton Systems, Inc. received a $249,712 Project Grant award from the Department of Energy Office of Science on February 22, 2021 to develop a fast, scalable, automated, one-pot process for assembly of DNA oligonucleotides into large gene sequences. The work will be performed in Chelmsford, Massachusetts through February 21, 2022. The award is being made under the Office of Science Financial Assistance Program (CFDA #81.049), which supports basic research to deliver scientific discoveries and...

Sequegenics LLC received a $251,073 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041). The grant supports development of low-cost and scalable methods for creating genomic databases using long-read next-generation DNA sequencing technologies. This aligns with the program's goals of fostering innovation in engineering research. The one-year project period runs from August 1, 2021 through July 31,...