Project Grant R25AG092297
- The Icahn School of Medicine at Mount Sinai received a $3,548,990 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the influence of stress on the expression of neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) mouse models. The goal is to test the hypothesis that promoting stress resilience could prevent or delay the emergence of AD-associated NPS. The 4-year project, starting on Sep 1, 2025, will examine how stress susceptibility...
- This $999,975.63 federal Project Grant, awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research by the Icahn School of Medicine at Mount Sinai to investigate the molecular mechanisms behind the increased vulnerability of the APOE4 gene to Alzheimer's disease and identify potential new therapeutic targets. The award period runs from April 1, 2025, to March 31, 2028. The Icahn School of Medicine at Mount Sinai is a leading...
- This federal Project Grant award of $463,916.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai. The funding will support a 2-year research project to identify a novel cytoplasmic activation platform for the caspase-2 enzyme, referred to as the "Ankosome", which may play a role in neuronal cell death in Alzheimer's disease. The project aims to elucidate the molecular...
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- The University of California, San Francisco (UCSF) was awarded a $109,084 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) on August 15, 2025 to support the UCSF Research in Alzheimer's Disease and Dementia (RADD) Summer Intern Program. This program will annually provide five public high school students from underrepresented backgrounds with research internships in UCSF laboratories focused on improving understanding and treatments for Alzheimer's disease and...
- This federal Project Grant award of $145,566 from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting research at the Icahn School of Medicine at Mount Sinai to investigate how the brain accumulates and utilizes "cognitive maps" - internal neural representations that enable flexible behavior and memory recall. The research aims to provide insights into the neuronal coding deficits underlying cognitive decline, with the goal of informing therapeutic...
- This $422,500 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) will support research to examine the drivers of high out-of-pocket spending and burdensome care for older adults with serious illness. The study aims to better understand how insurance generosity affects out-of-pocket spending and care experiences for this population, particularly at the onset of serious illness. The research project will...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a Project Grant in the amount of $4,035,962.00 to the Icahn School of Medicine at Mount Sinai (ISMMS) on September 15, 2025. The grant is titled "Examining Unique Markers and Risk Factors for AD/ADRD in Foreign- and Native-Born Older Chinese Americans: A Study of Social Determinants of Health, Sleep Patterns, Neuroimaging, and Plasma Biomarkers." The project aims to...
- The U.S. Department of Defense's Defense Health Agency awarded a $319,204 Project Grant to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on "Advanced Brain Age Modeling in Multiple Sclerosis: Toward a Prognostic Biomarker for Personalized Medicine." The award, which runs from August 15, 2024, to August 14, 2026, is part of the Military Medical Research and Development program (CFDA 12.420). This program supports biomedical research initiatives aimed at...
- This Project Grant award, valued at $2,129,396.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award aims to develop and validate engineered adeno-associated viruses (AAVs) that can selectively knock down the follicle-stimulating hormone receptor (FSHR) in neurons within brain regions vulnerable to Alzheimer's disease. This research seeks to understand the role of FSH signaling in cognitive decline and Alzheimer's...
The Icahn School of Medicine at Mount Sinai received a $307,801 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) to develop and implement the Postbaccalaureate Alzheimer's Disease Development Initiative (PADDI), a two-year program to train postbaccalaureate students about Alzheimer's disease and related dementia research methodologies and the ethical conduct of research. The program aims to address a lack of ethnic and racial diversity among Alzheimer's disease researchers, regulators, and research staff. PADDI researchers will spend 75% of their time as clinical research coordinators and 25% on didactic and professional development activities. The award period runs from September 20, 2025 through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $307.8k | 9/16/25 |