This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $602,956 to the University of Alabama at Birmingham (UAB) to conduct research on the molecular mechanisms underlying ciliopathy-associated structural birth defects. The research aims to identify and characterize genetic variants that disrupt cilia function, leading to developmental disorders. Key...
This $1,134,576 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research at Worcester Polytechnic Institute (WPI) focused on identifying new genes and signaling networks that regulate primary cilia assembly and remodeling in response to environmental stress. The 5-year project will leverage advanced molecular genetics, proteomics, and live cell imaging techniques in C. elegans and...
This $215,113 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to study the coordination and force transmission of beating cilia. Cilia are tiny, slender structures that extend from cells and move fluid through wave-like motion. This project will investigate how coordination of cilia is maintained in the single-celled organism Tetrahymena, and how changes to fluid resistance and connections between cilia affect their...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $275,100 to fund research focused on understanding the structure and function of proteins involved in intracellular transport within human cells. The research will utilize nuclear magnetic resonance (NMR) spectroscopy and other biophysical methods to investigate how structurally disordered regions of proteins, such as the dynein...
This $291,710 Project Grant awarded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program supports an integrative structural and functional study to dissect the regulatory mechanisms of ciliary motility. The project aims to enhance the understanding of motile cilia and flagella, cellular structures responsible for the locomotion of many single-celled eukaryotes and the movement of fluids in multi-cellular organisms. The study will focus on investigating the...
The National Institute of General Medical Sciences (NIGMS) awarded a $371,250 Project Grant under CFDA 93.859, the Biomedical Research and Research Training program, to the University of Alabama at Birmingham (UAB). The grant, effective January 1, 2025 through November 30, 2029, will support research to quantify the mechanisms of molecular motor proteins involved in transcription and protein homeostasis processes. Specifically, the research aims to define the elementary rate-limiting steps for...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded Emory University a $724,356 Project Grant under the Biological Sciences program (CFDA 47.074) to investigate the role of the protein ARL13B in controlling ciliary cyclic AMP (cAMP) signaling. The research aims to unravel the ciliary cAMP "signature", optogenetically stimulate cAMP signaling within normal and ARL13B-excluded cilia, investigate the role of ciliary cAMP signaling in remodeling...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports a Training Program in Cell, Molecular, and Developmental Biology (CMDB) at the University of Alabama at Birmingham (UAB). The $462,259 award, effective July 1, 2024 through June 30, 2029, will provide interdisciplinary training in basic cellular, molecular, and developmental processes to prepare predoctoral students...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to determine the mechanism by which the TULP3 protein regulates membrane receptor transport into cilia and its function in ciliogenesis. The 2-year, $125,000 award to The Leland Stanford Junior University aims to uncover the role of primary cilia in the generation of white blood cells. The research...
The federal Project Grant award R21NS140934, totaling $424,338, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The objective of this research project is to elucidate the molecular and cellular mechanisms by which G protein-coupled receptor (GPCR) signaling pathways regulate the activity of ependymal cilia in the brain. Specifically, the project aims...