This $450,000 National Science Foundation project grant will fund research into the relationship between primate gut microbiomes and behavioral traits. The University of Massachusetts will analyze behavioral and fecal samples from wild nonhuman primates to quantify the taxonomic diversity of gut microbes through 16S rRNA gene sequencing and identify functional genes through metagenomic sequencing. The research aims to examine potential associations between gut microbiome diversity, behavioral...
The federal Project Grant award R01AT013241, funded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), aims to develop and utilize new activity-based probes (ABPs) to directly characterize enzymatic function and microbial mechanisms within the gut microbiome. The $1,140,193 award, with a performance period from Sep 1, 2024 to May 31, 2029, will enable the research team to synthesize ABPs targeting specific enzyme classes in order to better...
This $854,736 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of robust statistical methods for analyzing longitudinal microbiome data. The project aims to create a comprehensive suite of tools to address key challenges in longitudinal microbiome studies, including addressing batch effects, identifying taxa associated with exposures/outcomes over time, detecting...
The National Institutes of Health (NIH) Office of the Director awarded a $1,389,728 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Trustees of Princeton University. The grant, titled "Genomic Recording Systems to Reveal Evolutionary Modifications in Primate Neocortex," aims to apply modern molecular tools and genomic analyses to discover the developmental and connectivity rules of sensory and higher-order areas in the common marmoset primate model....
This $781,525 Project Grant award from the National Institutes of Health (CFDA 93.351 - Research Infrastructure Programs) to the University of California, Davis aims to enhance the rigor and reproducibility of translational nonhuman primate models for genetic and regenerative therapies. The key products and services to be delivered under this 5-year award include: Using total-body positron emission tomography (PET) imaging to longitudinally monitor gene transfer and biodistribution in...
The National Institute of General Medical Sciences (NIGMS) awarded the University of California, Santa Cruz (UCSC) a $133,246 project grant under the Biomedical Research and Research Training Program (CFDA 93.859) to develop flexible Bayesian statistical methods for comprehensive analysis of microbial community dynamics using high-throughput sequencing data. The key objectives of this 3-year project are to: 1) create general methods for inferring microbial community dynamics in relation to...
The National Institutes of Health (NIH) awarded a $3,999,070 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of Louisiana at Lafayette's New Iberia Research Center (NIRC) to expand its macaque breeding capacity. The funding will support the construction of two new multi-run housing buildings with a total capacity of 1,600 macaque breeders and their offspring. This expansion is critical to accommodate the rapidly increasing research programs at NIRC,...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director, under the Research Infrastructure Programs (CFDA 93.351), provides $263,250 to Oregon Health & Science University (OHSU) to develop advanced transgenic technologies for creating genetically-altered rhesus macaque models. The project aims to adapt site-directed recombination methods, proven successful in rodent transgenics, to fundamentally advance the generation of transgenic non-human primates. The...
The National Science Foundation's Division of Integrative Organismal Systems awarded a $1,012,111 Project Grant to The Ohio State University to conduct research using machine learning and animal models to identify bacterial species and sub-networks within complex gut microbiomes that are essential for healthy animal development and growth. This interdisciplinary project leverages molecular and microbiological approaches, as well as legacy and cutting-edge machine learning tools, to analyze...
The federal Project Grant award R35GM154800 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The $759,234 award will fund a 5-year research project at the University of North Carolina at Chapel Hill to study host-microbiome coevolution and genetic variation in immunity using an insect model system. The project aims to understand the evolutionary forces maintaining host genetic variation related...