Project Grant R21NS145425
- This $445,500 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is supporting research at the University of Cincinnati to investigate the effects of methotrexate, a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia, on synaptic plasticity and its potential contribution to cognitive deficits in female survivors. The...
- This federal Project Grant award of $460,940 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research conducted by the University of Texas MD Anderson Cancer Center to investigate how genetic risk factors for glioma, a type of brain cancer, impact neurodevelopmental processes and potentially promote tumor formation. The research leverages human...
- This federal Project Grant award of $414,953 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is focused on understanding the role of inflammasomes, which are protein complexes that induce inflammatory responses, in driving sexual dimorphism in glioma therapies. The key objectives are to determine whether inhibiting the NLRP3 inflammasome can overcome...
- This federal Project Grant award of $135,513, provided by the National Cancer Institute under the Cancer Research Manpower (CFDA 93.398) program, supports research to elucidate the transcriptional mechanisms underlying cognitive impairment induced by cancer therapies, a critical issue affecting cancer survivors. The research, conducted by Beth Israel Deaconess Medical Center, Inc., a prominent academic medical center in Boston, Massachusetts, aims to identify candidate transcription factor...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,724 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Regents of the University of California, San Francisco (UCSF) on January 23, 2025. The project, titled "Hypoxia-Induced Misdirection: Understanding Postnatal Inhibitory Interneuron Migration in Neonatal Hypoxic Injury", aims to use computational approaches to identify altered...
- This Project Grant award, totaling $429,000.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will fund research at Oregon Health & Science University (OHSU) to investigate the fundamental interactions between astrocytes and oligodendrocytes, two major types of glial cells in the central nervous system, and how these...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support metabolomic research related to intracerebral hemorrhage (ICH) recovery. The $669,092 award, with a period of performance from May 2025 to April 2029, will leverage samples and data from two large genetic epidemiology studies of ICH to assess 5,400 metabolites and identify...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $361,975 to support research focused on developing chemical strategies for imaging and manipulating astrocytes in the brain. The project aims to expand the capabilities of an astrocyte-targeting chemical tag to enable direct visualization and modulation of astrocyte...
- This $488,232 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is funding research by The Washington University to explore the mechanisms by which astrocytes, a type of glial cell, support the metabolic needs of neighboring neurons in the brain. The 5-year project aims to investigate the regulation of intracellular and...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $226,112 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Colorado-Denver. The grant is focused on leveraging sex differences to understand the brain's macrophage immune response to perinatal hypoxic ischemic encephalopathy (HIE), a leading cause of death and disability in newborns. The research aims to determine the primary...
This $445,500 federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of perinatal testosterone in programming behavioral and astrocyte responses to early life chemotherapy. The research, conducted by the University of Cincinnati, aims to better understand the neurobiological changes that link early life cancer and chemotherapy exposure to cognitive deficits, with a focus on sex differences in astrocyte function. The project will leverage a mouse model of acute lymphoblastic leukemia and chemotherapy exposure to explore how the perinatal testosterone surge in males may alter astrocyte calcium signaling and contribute to the development of executive function and memory deficits observed in some childhood cancer survivors. The award period extends from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $445.5k | 7/31/25 |