Project Grant R21NS145070
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $220,050 to The Children's Hospital of Philadelphia Research Institute under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 1, 2025, for a five-year project concluding July 31, 2030. This Project Grant supports research to advance clinical trial readiness for SYNGAP1-related disorder (SYNGAP1-RD), a rare monogenic...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development awarded a Project Grant totaling $147,037 to The Children's Hospital of Philadelphia Research Institute on July 21, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This award supports a longitudinal neurodevelopmental research initiative designed to identify optimal electrophysiological markers for predicting developmental outcomes in infants. The project...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Children's Hospital of Philadelphia Research Institute a $775,490 Project Grant (CFDA 93.853 – Extramural Research Programs in the Neurosciences and Neurological Disorders) commencing June 1, 2026, and concluding April 30, 2028. The grant supports development and validation of a composite Interferon Signaling Response (ISR) biomarker to guide therapeutic decision-making in...
- Federal Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $2.38 million Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 10, 2025, with a completion date of August 31, 2028. This award funds a three-year research initiative investigating neural markers of late language emergence in preschool children born very and extremely preterm. The...
- Federal Project Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $489,500 Project Grant award, effective May 1, 2026, through the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year research initiative investigates the molecular mechanisms underlying BLOC1S1-related leukoencephalopathy, a rare neurological condition...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Children's Hospital of Philadelphia Research Institute a Project Grant of $221,400 (obligated August 1, 2025) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The five-year award (through July 31, 2030) funds research investigating the role of the c-Jun N-terminal kinase (JNK) signaling pathway in neurodevelopmental disorders...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Children's Hospital of Philadelphia (CHOP) a Project Grant totaling $719,498 (awarded August 1, 2025; completion July 31, 2030) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research project investigates the neurological pathophysiology of disrupted O-glycosylation in congenital disorders of glycosylation (CDG),...
- Federal Project Grant Award Summary The Children's Hospital of Philadelphia (CHOP) received a $356,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) on May 15, 2026, with completion targeted for April 30, 2028. The award funds research to analyze disease trajectories of rare genomic variants contributing to lesional brain disorders, specifically childhood...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $1,049,035 to The Children's Hospital of Philadelphia Research Institute on June 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This two-year project, concluding May 31, 2027, supports database harmonization and creation of outcome assessment and prediction tools for metachromatic leukodystrophy (MLD), a rare,...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Boston Children's Hospital a $674,950 Project Grant effective January 16, 2026, through December 31, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative will advance fundamental knowledge of top-down sympathetic nervous system control by dissecting neural circuits that regulate vital...
The Children's Hospital of Philadelphia received a $219,658 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective May 19, 2026, with completion targeted for April 30, 2028. The award funds research and development of wearable magnetoencephalography (MEG) technology using optically pumped magnetometer (OPM) devices to improve presurgical language mapping in pediatric epilepsy patients. The research aims to address significant limitations of conventional cryogenic MEG systems, which require patient immobility and maintain suboptimal detector-to-brain distances in pediatric populations, resulting in reduced sensitivity and diagnostic yield. The deliverables under this grant include validation of language mapping foci generated by wearable OPM-based MEG systems compared to conventional MEG in cases of successful conventional imaging, and improved diagnostic interpretation of functional brain maps in cases where conventional cryogenic MEG produces equivocal or insufficient results. By leveraging scalp-mounted detectors that tolerate head motion and provide increased sensitivity, the research is designed to enhance the diagnostic capability of MEG-based functional brain mapping for approximately 48 pediatric epilepsy patients, ultimately supporting more precise surgical planning while protecting eloquent cortical language areas.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $219.7k | 5/20/26 |