This federal Project Grant award of $660,632 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research aimed at understanding the structure and dynamics of the fusion pore, a critical component of the membrane fusion process that underlies neuronal function. The key objectives of the research are to: 1) leverage a novel reconstituted system to...
This Project Grant award of $270,434, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by Princeton University to investigate the spatiotemporal regulation of mRNA and its role in neuronal remodeling during morphogenesis. The project will leverage Drosophila models to characterize the localization and motility of the chickadee (chic)...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $144,362 to Drexel University to investigate the role of the PERK kinase in regulating the localization of neuroprotective growth factors in neurons. The 2-year and 7-month project, which began on July 17, 2024, aims to define how PERK interacts with the CaMKII kinase to...
This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
This $274,218.64 Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to Brandeis University will support research into the mechanisms underlying exosome release from neurons. The grant aims to determine how exosomes are generated from the endosomal system in neurons and explore neuronal exosome and endosome biology in an animal model. The grantee will manipulate the ESCRT and MUNC13-4/RAB11 pathways to investigate endosomal dynamics...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $481,126 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Chicago. The grant supports research to structurally and functionally characterize how the UNC-6/Netrin axon guidance cue complexes with the UNC-5 receptor to generate repulsive signals for neuronal wiring, in contrast to the UNC-6-UNC-40/DCC attractive complexes. The...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into the...
This Project Grant award of $244,154, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at the Albert Einstein College of Medicine to investigate the regulation of presynaptic gene transcripts during synaptogenesis. The research, conducted over the period from September 1, 2024 to June 30, 2027, will leverage the genetic accessibility and...
This $563,343 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, supports research conducted by New York University (NYU) to investigate the physical, molecular, and cellular mechanisms underlying tissue guidance and tissue splitting during nervous system development. The research uses the posterior lateral line primordium migration in zebrafish as...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", is funding research at Duke University to investigate the role of human-specific non-coding genomic sequences in regulating RNA splicing during cortical development and their implications for neurological diseases. The $147,656 award, granted on June 16, 2025, supports a research...