Project Grant R21NS143130
Award Date
5/15/25
Completion Date
4/30/27
Dollars Obligated
$446K
Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Ohio, USA
Similar Awards
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $1,780,906 in funding to Rutgers, The State University of New Jersey to identify novel biomarkers and develop therapeutic strategies for chemotherapy-induced cognitive impairment (CICI), also known as "chemobrain." The key objectives are to evaluate whether a PARP1 inhibitor (veliparib) can prevent methotrexate-induced cognitive deficits in mouse models, determine which neural...
This federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) totaling $1,239,420.00 supports a longitudinal observational study to assess the role of interoception (the brain's processing of bodily sensations) in chemotherapy-induced peripheral neuropathy (CIPN) among 120 cancer patients receiving taxane or platinum chemotherapy. The study, conducted by the University of Maryland, Baltimore, will include functional brain imaging,...
This federal Project Grant award of $450,313.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research by The Johns Hopkins University to investigate the potential of MAP4K4 inhibition to prevent chemotherapy-induced peripheral neuropathy (CIPN). The researchers will test the hypothesis that inhibiting the MAP4K4 protein can protect peripheral...
The National Cancer Institute (NCI) awarded a $1,474,236 Project Grant (CFDA 93.394 - Cancer Detection and Diagnosis Research) to The Children's Hospital of Philadelphia (CHOP) to develop a novel positron emission tomography (PET) biomarker for quantifying synaptic density changes in the brain following radiation therapy. The key products and services to be delivered under this 4-year grant include: Establishing the methodology for using quantitative PET imaging with a novel synaptic density...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate synaptic plasticity mechanisms that protect and refine local neural circuits. The $466,757 award to the University of Texas at Austin aims to advance understanding of how synapse structure supports learning and memory, with a focus on dendritic spines and the regulation of synaptic active zones. The research will use...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $816,554 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to The University of Texas MD Anderson Cancer Center to develop and validate a mouse model of chemotherapy-induced peripheral neuropathy (CIPN) associated with colorectal cancer. The project aims to assess the impact of surgery and tumor growth on the subsequent development of sustained pain hypersensitivity in response to an...
This $443,354 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate metabolic dependencies and resistance mechanisms in pediatric diffuse midline glioma (DMG) brain tumors harboring the H3K27M mutation. The research aims to understand how targeting the hexosamine biosynthetic pathway, either alone or in...
The National Institutes of Health's National Cancer Institute awarded $331,085.91 under the Cancer Research Manpower federal grant program (CFDA 93.398) to Brigham & Women's Hospital Inc. on February 1, 2021 for completion by September 30, 2022. The project grant funding will support research investigating the role of cellular senescence in chemotherapy-related cognitive impairment and the contribution of microglia to chemotherapy-induced senescence in the brain. Specifically, the grantee...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $706,959 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of California, Davis. The 5-year grant, awarded on September 18, 2024, will support research to elucidate the molecular signaling mechanisms that regulate the growth, stabilization, and functional maturation of dendritic spines and their associated synapses during activity-dependent...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $397,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the Massachusetts Institute of Technology (MIT). The grant, effective May 1, 2025 through April 30, 2030, will support innovative research to study fundamental principles linking neurodevelopmental processes to the functional organization of neural circuits. The goal is to...