Project Grant R21NS142801
- This $616,200 Project Grant was awarded on February 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to explore the influence of neuromelanin, a dark pigment, on dopaminergic neurons in Parkinson's disease. The project aims to develop a novel mouse model that accumulates neuromelanin in dopamine neurons to study the resulting...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 3-year, $113,268 Project Grant to Texas A&M University System Health Science Center to conduct research on the role of endoplasmic reticulum-exit site upregulation in neuroprotection against Parkinson's disease. This project, funded under NINDS's Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), aims to investigate whether increases in SEC24D-containing endoplasmic...
- This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
- The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, awarded The Washington University a $1,227,794 Project Grant to conduct research on "Precision Mapping of Parkinson's Disease Pathophysiology in the Somato-Cognitive Action Network's DBS Targets." The goal is to evaluate the connectivity of motor systems, including the somato-cognitive action...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $670,600 to The Johns Hopkins University to conduct research on the role of microglia in Parkinson's disease (PD) cognitive and motor impairment. The research aims to better understand the relationship between a microglial-specific radioligand, [11C]CPPC, and the severity of...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $231,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Rochester. The grant, which runs from March 1, 2025 to January 31, 2028, aims to develop culturally-tailored approaches to improve equity in palliative care research and service delivery for individuals with Parkinson's disease, Lewy body dementia, and related disorders living...
- This federal Project Grant award of $220,260.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of the grant is to investigate the role of the RNA-binding protein ELAVL3 in regulating glutamate and dopamine receptor signaling in the striatal neurons of the brain, with the goal of understanding the molecular mechanisms underlying striatal...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for Parkinson's disease (PD) and Alzheimer's disease related dementias (ADRD). The $793,535 award, with a project period from December 1, 2024 to November 30, 2029, will fund studies...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $418,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to President and Fellows of Harvard College's Harvard T.H. Chan School of Public Health. The grant will support a comprehensive investigation into the potential role of infections in the development of Parkinson's disease and related non-motor symptoms. The study will leverage data and blood samples from two large prospective studies to measure the immune response to over 1,800 viral and bacterial proteins in 120 individuals who developed Parkinson's disease and 120 controls. This research aims to improve the understanding of the underlying causes of Parkinson's disease, which currently lacks effective treatments to halt or reverse disease progression. The project will run from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $418.0k | 7/30/25 |