This $429,000 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research on somatic instability of CAG repeats in spinal and bulbar muscular atrophy (SBMA). The research aims to evaluate the tissue selectivity and temporal relationship of somatic instability in aging SBMA mouse models and human SBMA muscle biopsies, and investigate the role of somatic expansion in the disease process. The ultimate goal is to develop a mechanistic understanding of SBMA pathogenesis and identify new therapeutic directions for this neurodegenerative disease. The award recipient is Thomas Jefferson University, doing business as Sidney Kimmel Medical College, a private non-profit academic medical center in Philadelphia, Pennsylvania. The project period spans from May 2025 to April 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $429.0k | 5/14/25 |