Federal Grant Award Summary

Yale University received a $462,151 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded May 19, 2026, with completion targeted for April 30, 2028. The award funds basic research investigating the genetic and molecular mechanisms underlying cerebral cavernous malformations (CCMs), a cerebrovascular disease characterized by vascular lesions in the central nervous system that cause seizures and hemorrhagic stroke. The research focuses specifically on CCM3 genetic subtype mutations, which produce the most aggressive form of the disease.

The project deliverables include comprehensive genomic, transcriptomic, and single-cell chromatin accessibility analyses of CCM tissue specimens from donated brain samples harboring multiple lesions at different anatomical locations. Research outputs will advance understanding of the genomic, transcriptomic, and epigenetic landscape of CCMs and characterize the contribution of the local brain microenvironment to lesion formation. Through analysis of additional surgical specimens, the research team will identify unifying molecular principles of CCM pathogenesis, with findings intended to inform future therapeutic development for this rare neurological condition. The performance location is New Haven, Connecticut.