This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of the AMPK signaling pathway in regulating oligodendrocyte development and myelination during postnatal brain development. The $232,524 award, effective from April 1, 2025 to March 31, 2027, will be used by the awardee, the Research Foundation for the State University of New York, operating as Stony Brook University, to conduct studies in mice that assess the impact of modulating AMPK activity, both pharmacologically using metformin and through conditional genetic knockout, on oligodendrocyte lineage dynamics and the myelination process. The project aims to fill knowledge gaps on the regulation of energy metabolism in oligodendrocytes and the translational potential of targeting the AMPK pathway to influence developmental myelination, which has implications for understanding and treating demyelinating disorders.