This federal Project Grant award, provided under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program administered by the National Institute of Neurological Disorders and Stroke (NINDS), aims to define the pathobiological trajectory of early-onset neurological disorders in relation to methylglyoxal, microvascular leakage, and inflammation in HIV-1 infected humanized mouse models. The $652,375 award will also assess whether lowering...
This federal Project Grant award for $853,135 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research at Dignity Health's St. Joseph's Hospital and Medical Center in Phoenix, AZ to study the role of the complement C3A receptor in exacerbating brain injury and functional impairment following ischemic stroke. The research aims to...
This Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of complement-mediated inflammation in exacerbating stroke outcomes in mice with type 2 diabetes. The total award amount is $604,795.00 and the project period runs from December 1, 2024 to November 30, 2029. The awardee, Northern...
This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
The University of Rhode Island Research Office received a $413,729 Project Grant award on September 22, 2023 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding will support research to investigate the molecular links between stroke, the actin cytoskeleton, and Alzheimer's disease pathogenesis. The proposed work will use induced...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) provides $441,715 to Loma Linda University (LLU) to study the protective role of blood-borne immune cells, particularly monocytes/macrophages, in improving outcomes after delayed recanalization in a rodent model of permanent middle cerebral artery occlusion. The research aims to...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to evaluate social brain function in people living with HIV (PWH). The $733,355 award, effective March 1, 2025 through January 31, 2030, will utilize well-validated fMRI paradigms to examine neural circuits and performance related to two core social cognitive constructs: perceiving social cues (e.g., facial expressions, prosody) and...
This $624,583 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research at the University of Washington to identify potential therapeutic targets for preventing ischemic stroke. The project will leverage existing plasma samples, genomic data, and electronic medical records from the Heart and Vascular Health Study to evaluate...
This Project Grant award for $665,171.00, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to improve outcomes for individuals with HIV-associated opportunistic infections like cryptococcal and TB meningitis. The key objectives are to: 1) define CSF drug concentrations or AUC/MIC ratios that predict fungal clearance, 2) determine the relationship between...