Project Grant R21NS140948

Award Date 4/15/25
Completion Date 3/31/27
Dollars Obligated $236K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to advance the understanding of human brain development and the origins of neurodevelopmental diseases. The $1,008,977 award to the Regents of the University of California, San Francisco will fund research focused on illuminating the complexity of human cortical...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research on the regulation of phase separation in neuronal heterochromatin. The $313,779 award to the University of California, San Diego, will run from August 1, 2024 to May 31, 2029. The research aims to explore the role of the protein Ki-67 in the formation of...
This $127,145 federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research aimed at unraveling the regulatory mechanisms governing chromatin organization and gene transcription during neural development in the Drosophila model organism. The key products and services to be delivered under this 2-year grant include:...
This $161,922 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will support research to investigate the spatiotemporal regulation of mRNA and its role in neuronal remodeling during morphogenesis. The principal investigator will use CRISPR/Cas13-based techniques to characterize the localization and motility of the chickadee (chic)...
This Federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $147,656.00 to Duke University to conduct research on the role of human-specific non-coding sequences in regulating RNA splicing and isoform expression during cortical development and neurological disease. The research aims to 1) test the function of intronic human-specific...
This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop enhanced genetic targeting techniques for specific neuronal populations. The total funding amount is $689,689, with a project period from July 1, 2024 to June 30, 2026. The key products and services to be delivered under this award include: 1) designing and...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $438,342 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of California, San Diego (UCSD) to study the regulatory mechanisms of the anaphase-promoting complex (APC) and its role in neurodevelopmental disorders. The grant supports research to examine how the APC ubiquitin ligase complex recognizes and ubiquitinates the chromosome-passenger...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $481,250 to support the development of a synthetic biological system for manipulating subcellular RNAs and proteins in growth cones or synapses of specific neuron subtypes. The award, provided to President and Fellows of Harvard College, will fund research aimed at enabling...
This federal Project Grant award for $444,599.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research investigating the impact of neuronal activity on oligodendrocyte progenitor cell proliferation, survival, and differentiation. The primary awardee, the University of Colorado-Denver, will use designer receptor technology to manipulate...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $582,883 to the Regents of the University of California at Riverside to conduct research on the role of CAS adaptor proteins during cortical axon pathfinding. The objective is to investigate how adhesive and instructive signaling pathways are interpreted and coordinated within...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $236,250 to the University of California, Los Angeles (UCLA) to elucidate how alternative splicing of the DPF2 subunit of the chromatin remodeling BAF complex regulates epigenetic programs during brain development. The award, with a performance period from Apr 15, 2025 to Mar 31, 2027, will utilize CRISPR/Cas9-edited stem cell lines and mouse models to determine how the DPF2 splicing switch controls transcriptional and chromatin regulatory programs, as well as neuronal maturation, in glutamatergic neuron differentiation and the aging mouse brain. The research aims to map genome-wide BAF complex recruitment and chromatin accessibility changes throughout brain development and aging.

Generated 4/29/25, 3:16 AM