The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, awarded a $128,286 Project Grant to Rutgers, The State University of New Jersey on September 1, 2025. The grant supports research to investigate the mechanism by which the protein PAR1C regulates AMPA receptor trafficking and synaptic plasticity in the brain. The research aims to understand how PAR1C...
This federal Project Grant award of $461,889.00, made by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to study the mechanisms controlling the activity of NTSHSD2 neurons, which are key regulators of sodium appetite. The research aims to determine how aldosterone-mineralocorticoid receptor signaling regulates the activity of NTSHSD2 neurons, and to...
This Project Grant award, valued at $104,298.00 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to characterize the biophysical properties and pharmacological rescue of two disease-related variants of the GRIN1 gene. The experiments will utilize protein chemistry, molecular biology, and patch-clamp electrophysiology techniques in...
This federal Project Grant award of $429,514.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the regulation of myelin acquisition and maintenance in the adult central nervous system (CNS). The key objectives are to determine the activity dependence of myelin acquisition in the adult spinal cord and the role of the Tuberous Sclerosis...
This Project Grant award, totaling $2,813,759.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate the role of the noradrenergic signaling pathway and its integration with glutamatergic signaling in modulating neurovascular coupling, and how degeneration of noradrenergic neurons in Alzheimer's disease may alter...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $168,321 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regents of the University of Michigan. The grant, titled "Investigating Mechanisms of NPC1 Proteostasis in Human Neurons", aims to determine the effectors mediating NPC1 folding, trafficking, and degradation in neurons for Niemann-Pick disease type C, a rare lysosomal storage...
This federal Project Grant award of $459,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the anatomical and physiological changes associated with molecular layer heterotopia (MLH), a neuronal migration defect observed in various neurodevelopmental disorders. The award to the New York Institute of Technology (NYIT) will fund studies...
This federal Project Grant award of $427,625 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant will fund research to examine the conformational dynamics and regulatory mechanisms of the KCNH family of ion channels, which play a key role in controlling cell excitability. The research will leverage non-canonical amino acid (NCAA) technology to investigate the voltage sensor domain and S4...
This federal Project Grant award for $654,287.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports a computational neurocognitive impairment study in multiple sclerosis (MS). The goal is to provide a psychometrically valid and biologically informed model of cognitive status in relapsing-remitting and progressive MS using computational modeling...
This federal Project Grant award, totaling $108,486.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research conducted by the University of Florida to explore the role of nonmuscle myosin IIB (NMIIB) in regulating synaptic actin dynamics and its implications for learning, memory, and drug addiction. Key objectives include using...
This federal Project Grant award of $274,750.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to understand the role of the CNNM2 protein in regulating magnesium homeostasis and its impact on neuronal function and development. The research, conducted by Rutgers The State University of New Jersey, aims to characterize the neuronal expression and protein composition of CNNM2, and investigate how mutations in CNNM2 disrupt magnesium flux in both mouse and human models. The project period runs from February 1, 2025 to January 31, 2027.