The University of Michigan was awarded a $248,708 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research to develop and characterize a diurnal rodent model for Familial Natural Short Sleep (FNSS) to study the impact of sleep on neural network function. The project aims to determine the effects of the FNSS-associated DEC2-P384R mutation on circadian behavior and sleep in the diurnal grass rat model, as well as measure the differential impacts of sleep and wake states on neural network functional recordings in the mutant versus normal grass rats. This research is expected to provide novel insights into the relationship between sleep and circadian rhythms and enable future studies on factors like chronic sleep deprivation, irregular light schedules, and mood disorders. The award period runs from March 1, 2025 to February 28, 2027.
Generated 3/18/25, 3:28 AM