This Project Grant award for $211,875.00, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on characterizing the development and function of medulla visual projection (MEVP) neurons in the Drosophila visual system.
The key objectives of this exploratory two-year project conducted by New York University School of Medicine are to: 1) use lineage tracing to determine which neuroblasts give rise to MEVP neurons and perform transcriptomic analysis to profile their gene expression; and 2) investigate the mechanisms that direct MEVP neurons to send dendritic projections perpendicularly to the majority of medulla neurons and axonal projections into the central brain. The research aims to advance the scientific understanding of how the layered structure of the medulla neuropil is organized, and potentially shed light on the role of tangentially projecting neurons in the developing human brain.
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