Project Grant R21NS138711
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
- The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,685 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). The funding will support the development of an injectable hydrogel with an integrated urokinase plasminogen activator (uPA) motif and plasmid DNA (pDNA) platelet-derived growth factor B (PDGFB)-lipoplexes to be loaded into the...
- This Project Grant award of $438,625.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of California, San Diego (UCSD) to characterize and augment a novel pro-survival mechanism in neurons during ischemic brain injury. The research aims to investigate the role of the protein INF2 in driving "actinification", a...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $652,497 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program to The General Hospital Corporation (Massachusetts General Hospital) for the project "Defining the Neurological Substrates of Proximal Upper Extremity Motor Control and Recovery After Stroke". The 5-year project aims to (1) determine baseline relationships between the...
- This Project Grant award of $192,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to define the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The award, effective December 1, 2024, will enable the University of Utah to leverage innovative murine models and novel ceramide biosynthesis...
- This $490,049 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by Shearit LLC to evaluate the efficacy of their Lamiflo drug for reducing ischemic penumbra and core volumes in acute ischemic stroke. The 1-year study will test Lamiflo, a drag-reducing polymer that enhances blood flow, in rat models of middle cerebral artery...
- The National Institute on Aging, part of the Department of Health and Human Services' National Institutes of Health, awarded $3,387,438 under the Aging Research program (CFDA 93.866) to The Ohio State University Office of Sponsored Programs on September 19, 2022. The three-year project grant aims to develop and test a novel neuroprotective agent, TAT-M2NX, to provide both acute and sustained synaptic protection following acute ischemic stroke. The research seeks to characterize the agent's...
- Dr. Mark Etherton of Massachusetts General Hospital will receive $338,509.06 from the National Institute of Neurological Disorders and Stroke to study microvascular dysfunction in cerebral small vessel disease and stroke outcomes over four years from July 2021 through April 2026. This Project Grant will support research to elucidate the relationship between white matter microvascular function, ischemic tissue outcomes, and chronic microvascular dysfunction's contribution to structural injury and...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $671,988 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Winifred Masterson Burke Medical Research Institute, Inc. The project focuses on understanding the cross-talk between two cell death pathways, sarmoptosis and ferroptosis, in the context of intracerebral hemorrhage (ICH), a type of stroke. The research aims to explore how the accumulation...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $429,000 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Oregon Health & Science University (OHSU). The purpose of this 2-year grant is to investigate mechanisms of white matter injury following an ischemic stroke and evaluate the neuroprotective effects of the CK2 inhibitor CX-4945 on preserving white matter function. The project aims to utilize an in vivo rodent model of selective subcortical white matter injury, along with longitudinal neuroimaging and behavioral assessments, to better understand sexually dimorphic, age-dependent recovery of white matter mitochondrial dynamics and axonal function after ischemia. The findings could inform development of targeted therapies to protect white matter and improve outcomes for stroke survivors.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $5.5k | 7/31/25 | ||
| Not listed | $423.5k | 7/28/25 |