This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $147,656.00 to The Medical College of Wisconsin, Inc. to conduct research on the mechanisms underlying neuronal excitability and pain in Fabry disease. The key objectives are to: 1) Identify which voltage-gated sodium channels exhibit altered biophysics in Fabry disease...
This Project Grant award of $597,999.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on understanding the neuronal populations and central sensitization mechanisms underlying mechanical allodynia, a debilitating condition where normally innocuous touch or movement becomes painful after an injury. The key objectives of this 5-year...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Drug Use and Addiction Research Programs (CFDA 93.279), provides $415,519 to The Regents of the University of California, Berkeley to conduct research on the role of the SCN1B gene in susceptibility to neuropathic pain. The goal is to investigate whether SCN1B, which encodes a subunit of voltage-gated sodium channels, plays a key part in the development of tactile allodynia...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $453,104 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The University of Texas Southwestern Medical Center to conduct research on ascending spinal pain circuits. The research aims to explore the role of two subtypes of spinal projection neurons, TACR1- and GPR83-expressing neurons, in transmitting chronic pain signals to the brain. The study will...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to advance scientific understanding and treatment of chemotherapy-induced painful peripheral neuropathy (CIPPN). The $5,666,172 award to New York University will fund research to examine the role of Schwann cell signaling mediated by PPARG and LRP1 in regulating cell survival, mitochondrial function, and neuroinflammation...
This federal Project Grant award, valued at $764,659.00 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of neurovascular interactions in neuropathic spontaneous pain. The principal investigators at the University of Cincinnati will characterize how local vascular movement triggers neuropathic spontaneous pain,...
This $130,584 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research on the negative regulatory mechanism of mechanically activated Piezo2 channels by the protein TMEM120A/TACAN. The research aims to investigate how TMEM120A, initially proposed as a mechanosensitive ion channel, actually functions as a lipid modifying enzyme that...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $329,551.00 in funding to Rutgers, The State University of New Jersey to study the regulation of the PIEZO2 ion channel by membrane lipids. The key objectives of this 2-year research project are to: 1) identify the molecular determinants of the inhibitory effects of phosphatidic acid (PA) and lysophosphatidic acid (LPA) on...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to investigate a novel, non-opioid spinal analgesic mechanism for treating high impact chronic pain conditions. The $664,772 award to The University of Texas Southwestern Medical Center aims to evaluate the signaling pathways involved in the activation of the...
This federal Project Grant award of $499,979 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to uncover astrocyte contributions to neuropathic pain. The project aims to 1) determine how peripheral nerve injury alters dorsal horn astrocyte function, 2) elucidate how targeted interventions control dorsal horn astrocyte function after nerve...