This $644,008 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research on the role of non-vesicular lipid transport at endoplasmic reticulum-plasma membrane (ER-PM) contact sites in phosphoinositide signaling during early dendrite development. The study aims to determine whether the lipid transport protein NIR2 is a...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) totaling $1,002,148 to The Regents of the University of California, Berkeley (UC Berkeley). The grant, with a period of performance from January 1, 2025 to November 30, 2029, will support research to determine how levels of the lipid phosphatidylinositol 3-phosphate (PI(3)P) are controlled and how they in turn...
This $1,417,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) funds the development of "Electrified Cryo-EM", a novel tool that can kinetically trap biological systems in their metastable, non-equilibrium states. The research aims to unravel the structural changes in neurons during an action potential across multiple length scales, from voltage-gated channel proteins to the synaptic junction. Specifically,...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $608,787 to the University of California, San Diego to investigate a novel mechanism for how dysfunctional mitophagy (selective autophagy of mitochondria) contributes to brain ischemia-reperfusion injury. The research aims to determine if inactivation of the...
This $249,750 federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to elucidate the molecular mechanisms by which the synaptic protein C1QL3 promotes excitatory synapse formation and function. The research aims to: 1) characterize the structural basis for C1QL3's interactions with binding partners Adgrb3 and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $390,000.00 to the University of Texas at Dallas to investigate the molecular mechanisms underlying focal cortical malformations and epilepsy. The research aims to: 1) determine how dysregulated MNK-eIF4E translational control contributes to the development of these focal...
This Project Grant award of $434,610 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports the development of light-triggered molecular tools critical for understanding the brain's neural network. The principal investigator, Dr. Nasri Nesnas of the Florida Institute of Technology, is collaborating with neuroscientists to design and use these tools to precisely manipulate calcium ion concentrations and enable temporal control of...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded Brandeis University a $846,469 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to elucidate how the ESCRT (Endosomal Sorting Complex Required for Transport) machinery is regulated and deployed in neurons. The research aims to develop new visualization and manipulation tools to study ESCRT dynamics in Drosophila neurons, including: 1) investigating the dynamics of...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $660,632 to fund research on the structure and dynamics of fusion pores during membrane fusion events in neurons. The research, to be conducted at the University of Wisconsin-Madison, aims to: 1) continue studying the regulation and kinetics of fusion pores formed between...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to dissect the role of calcium channel dysfunction in the pathogenesis of neurodevelopmental disorders (NDDs). The $743,995 award to the University of Maryland, Baltimore aims to evaluate the impact of Timothy Syndrome mutations on neuronal function using induced pluripotent stem cell-derived neurons and transgenic mice. Key research...