The University of Texas Health Science Center at Houston (UTHealth) received a $195,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to investigate the use of sharp wave ripple stimulation as a potential strategy to enhance memory function in individuals who have sustained a traumatic brain injury (TBI). The research will involve recording sharp wave ripple activity in the hippocampus of sham and TBI rats, and then testing whether optogenetic or pharmacological stimulation of hippocampal ripples can be used to improve memory in the TBI animals. By better understanding the impact of TBI on hippocampal function and sharp wave ripple activity, the research seeks to develop innovative therapeutic approaches to restore memory deficits associated with TBI. The award has an initial term from Jun 15, 2024 to May 31, 2026.
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