The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), has awarded a $243,220 project grant (R21NS136895) to Brigham & Women's Hospital Inc. The funding will support a 2-year research project titled "Defining the Substrates of Acyl Protein Thioesterase-1: Their Role in Modulating Alpha-Synuclein Toxicity." The project aims to identify the physiological substrates of the enzyme Acyl Protein Thioesterase-1 (APT1) and evaluate their role in modulating the toxicity of the neuronal protein alpha-synuclein, which is implicated in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. The research will employ both physiological and cellular approaches to address these key questions, which are crucial for the development of palmitoylation-based therapeutic strategies for these neurodegenerative diseases.
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