This federal Project Grant award of $492,250.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will support research by the Winifred Masterson Burke Medical Research Institute, Inc. to investigate the role of the protein SPARC in wound healing and fibrosis following spinal cord injury (SCI). The research aims to characterize the temporal...
This $536,617 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the mechanisms of neural regeneration in model organisms. The primary awardee, Oregon Health & Science University, will conduct experiments using planarians and zebrafish to investigate how adult neural stem cells can regenerate neural tissue and restore...
This $391,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop effective therapeutic strategies for spinal cord injury (SCI) by evaluating controlled PTEN deletion and chondroitin sulfate proteoglycans (CSPGs) degradation to promote axon regeneration and functional recovery. The key objectives are to: 1) Temporally evaluate...
This $424,875.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund a comprehensive study of gene transcription patterns in diverse classes of neurons that connect the brain to the spinal cord after spinal cord injury in a mouse model. The research team at Marquette University will use single-cell sequencing technologies to profile...
This federal Project Grant award of $458,154, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research conducted by Microcures Inc. to develop a nanoparticle-encapsulated siRNA formulation that targets the Fidgetin-like 2 (FL2) protein to promote tissue repair and functional recovery after spinal cord injury. The goal is to demonstrate the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $151,559 to Rensselaer Polytechnic Institute (RPI) from August 3, 2024 to July 31, 2026. The project aims to develop innovative magnetically responsive drug delivery electrospun fibers to improve regeneration after spinal cord injury (SCI). Specifically, the research will focus...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $469,898 to Yale University to conduct research on mechanisms supporting raphespinal tract plasticity and regeneration after spinal cord injury. The research aims to use anatomy, spatial transcriptomics, and intersectional in vivo chemogenetics to define the capacity and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $397,500.00 to the Massachusetts Institute of Technology (MIT) to study the fundamental principles linking neurodevelopmental processes to the functional organization of neural circuits that could enable network-scale regeneration. The 5-year award, starting on May 1, 2025,...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports development of a novel screening technology to identify FDA-approved drugs that can promote functional recovery in spinal cord injury (SCI). The $411,136 award to the Texas A&M University System Health Science Center will fund a 3-step screening platform using adult cortical...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", provides $427,625.00 to study whether electrical stimulation can enhance the capacity of neural stem cell transplants to improve recovery from chronic spinal cord injury. The primary goal is to determine if electrical stimulation supports the survival and differentiation of stem...