Project Grant R21NS135343

Award Date 8/1/24
Completion Date 6/30/26
Dollars Obligated $462K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Farmington, CT 06032, USA
Similar Awards
This $528,129 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to structurally and functionally characterize critical ubiquitinating and de-ubiquitinating enzymes implicated in human diseases. The overarching goal is to develop a detailed understanding of how ubiquitin-proteasome pathway (UPP) components recognize substrates and execute their function, which is crucial for developing new...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders will fund research to examine the role of a specific huntingtin (HTT) isoform, HTT1A, in the progression of Huntington's disease. The $100,060 grant awarded to the University of Massachusetts Medical School will investigate how HTT1A expression and its interaction with mutant HTT protein affect the...
This $666,728 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to enhance understanding of the molecular and cellular mechanisms underlying congenital hydrocephalus (CH). The grant supports the establishment of a large, diverse cohort of primary CH patients, with a focus on non-European populations, to enable comprehensive...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, funds research at Tufts University to develop a hybrid differentiation strategy for generating region-specific neural and oligodendrocyte cell populations from human pluripotent stem cells. The project aims to optimize protocols for rapidly differentiating region-specific...
This Project Grant award, totaling $478,732.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award, with a period of performance from July 2024 through June 2026, supports research by Seattle Children's Hospital to characterize the cellular features of expanded progenitor zones in the human cerebellum using in vitro techniques. The...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $457,875.00 in funding to the University of Connecticut Health Center (UCHC) to support research on the molecular mechanisms and heterogeneity of the inferior olivary nucleus development. The research aims to construct a 3D molecular atlas of the developing inferior olive...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,540,579 to the Regenerative Research Foundation to develop and validate a novel human cell-based model for studying frontotemporal dementia (FTD) caused by mutations in the MAPT gene. The key objectives are to generate a 3D cellular model incorporating cerebral cortex, striatum,...
This federal Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) will provide $2,357,335 to Boston University to conduct research on neuronal dysfunction in Down syndrome (DS) and its relationship to Alzheimer's disease (AD). The key products and services to be delivered include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids (COs) and assembloids (fused COs) to examine the cellular,...
This federal Project Grant award of $789,088 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop a novel, less invasive tool for ablating the choroid plexus to treat neonatal hydrocephalus. The primary recipient, Childrens Hospital Medical Center, will utilize advanced techniques such as recombinant adeno-associated virus (AAV) vectors and human...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $234,630 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The General Hospital Corporation (doing business as Massachusetts General Hospital) to study the role of the EIF4A2 gene in interneuron development. The research will utilize zebrafish models to examine the impact of EIF4A2 loss and gain of function on interneuron...

This $461,528 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to create the first human-based cellular model of Hao-Fountain syndrome. The award will enable researchers at the University of Connecticut Health Center to:

  1. Test the effect of Hao-Fountain syndrome-causing mutations on the enzymatic function of the USP7 protein (Aim 1)
  2. Evaluate the impact of these mutations on neuron differentiation potential and morphology (Aim 2)

The research will utilize patient-derived induced pluripotent stem cells, which will be differentiated into cortical neurons to establish the Hao-Fountain syndrome model system. This model will then be shared with the broader research community to accelerate understanding of this newly discovered rare pediatric neurodevelopmental disorder. A sub-award to Wesleyan University will support the reprogramming of patient fibroblasts into induced pluripotent stem cells, their expansion and cryopreservation, and subsequent differentiation into neural progenitors and cortical neurons for further analysis.

Generated 6/17/25, 2:55 AM