Project Grant R21NS130443
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $520,025 to the University of Connecticut Health Center on July 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop next-generation RNA inhibitors for ischemic stroke therapy. The research focuses on developing peptide nucleic acid (PNA) analogs, particularly gamma (γ) PNA-based microRNA-141-3p (mir-141-3p)...
- Federal Grant Award Summary Gentibio, Inc. received a $1.15M Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop tissue-engineered regulatory T cells (engTregs) as a therapeutic treatment for acute ischemic stroke. The award, effective August 15, 2025, through July 31, 2027, supports the development of an allogeneic, off-the-shelf...
- Federal Project Grant Award Summary Augusta University Research Institute, Inc. (AURI), doing business as Georgia Health Sciences, received a $462,933 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective January 1, 2026, through December 31, 2030. The award funds investigator-initiated research examining spreading depolarization (SD), a...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Stanford University a $125,685 Project Grant on August 9, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to develop a bioactive material intervention for post-stroke dementia. The research will culminate in the development of an injectable hydrogel embedded with urokinase plasminogen activator (UPA) and plasmid DNA encoding...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Alabama at Birmingham $540,236.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This Project Grant, effective September 1, 2025, through August 31, 2030, funds research targeting glial HUR (Human Antigen R), an RNA regulator that drives neuroinflammatory responses in acute ischemic stroke. The research aims to...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Massachusetts General Hospital $470,786 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on May 15, 2025, with completion targeted for March 31, 2030. This Project Grant supports investigator-initiated research examining the mechanisms linking aging, immune dysfunction, and vascular contributions to cognitive impairment and dementia...
- This $274,218.64 Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to Brandeis University will support research into the mechanisms underlying exosome release from neurons. The grant aims to determine how exosomes are generated from the endosomal system in neurons and explore neuronal exosome and endosome biology in an animal model. The grantee will manipulate the ESCRT and MUNC13-4/RAB11 pathways to investigate endosomal dynamics...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Maryland, Baltimore $602,065 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on March 5, 2026, with a completion date of December 31, 2029. This project grant supports fundamental neuroscience research investigating the molecular mechanisms by which SGLT2 (sodium-glucose cotransporter 2) regulates aquaporin-4 (AQP4)...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Wisconsin–Madison a Project Grant totaling $494,240 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective February 16, 2026, through January 31, 2031. This award funds a five-year research investigation into microRNA (miRNA) degradation mechanisms in post-stroke brain tissue, specifically examining...
- Grant Summary Oregon Health & Science University (OHSU) received a $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, with completion targeted for July 31, 2027. The award funds research to investigate post-ischemic protection of white matter following stroke, addressing a significant gap in understanding...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their biodistribution in stroke areas with and without pulsed focused ultrasound (PFUS) delivery; and 2) investigate the recovery from stroke following delivery of the engineered exosomes with or without PFUS. This work aims to advance the use of exosome-based therapies and PFUS technology to improve treatment outcomes for ischemic stroke patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 8/21/23 |