Project Grant R21MH140290
- The National Institute of Mental Health (NIMH) awarded a $837,131 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Yale University to improve the inclusion of individuals with intellectual disability in autism neuroscience research. The 5-year project, starting on February 1, 2025 and ending on December 31, 2029, aims to apply innovative technological and clinical approaches to collect neuroscience data from 70 children with autism and intellectual disability, as...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support a $831,412 investigation into the role of value learning in core features of autism in toddlers at Yale University. The project will examine value learning, or the process by which neutral stimuli gain attentional salience, in 18- to 30-month-old toddlers with autism spectrum disorder (ASD), typical development (TD), and developmental delays...
- The federal Project Grant award of $127,557 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a research project titled "Brain Aging in Adults with Autism Spectrum Disorder". The goal is to characterize age-related changes in neuroimmune profiles, immune cell phenotypes, and neuronal inflammation in adults with autism spectrum disorder (ASD) compared to unaffected controls using postmortem human brain tissue....
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding a 5-year, $175,017 study titled "Investigating Neural Predictors of Real-World Social Attention in Autism During Naturalistic Social Interactions." The project, led by researchers at the University of Houston System, aims to develop innovative, ecologically valid measures of visual attention and its neural mechanisms in autistic...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $752,596 to the University of South Carolina to conduct a longitudinal study examining autonomic nervous system (ANS) dysfunction and sensory processing in infants at elevated risk for autism spectrum disorder (ASD). The study aims to: (1) identify the presence, onset, and developmental trajectory of baseline ANS dysfunction; (2)...
- This Project Grant award of $746,183 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports a longitudinal study to evaluate preterm infants' autonomic nervous system dysfunction as a predictor of autism spectrum disorder (ASD). The study aims to: 1) assess preterm infants' autonomic nervous system dysfunction as an ASD-specific etiological mechanism, 2) examine how neonatal morbidities moderate the association between...
- This $124,488 Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) supports research to map cell type-specific isoform diversity in the human brain and dissect the mechanisms of alternative splicing in autism spectrum disorder (ASD). The grantee, the University of California, Los Angeles (UCLA), will conduct single-nucleus long-read sequencing of over 60 human prefrontal cortex samples, including 33 ASD cases and 30 controls, to fully...
- This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will fund research to investigate the impact of autism spectrum disorder (ASD) genetic risk on microglia-neuronal interactions. The $165,796 award, effective November 22, 2024 through June 30, 2028, will support the use of human stem cell culture and 3D cortical spheroid models to assess how ASD genetic risk affects microglia physiology and...
- This Project Grant award of $735,932 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to elucidate the cellular manifestations of positive symptoms, such as auditory hallucinations, in mouse models of two strong genetic predictors of schizophrenia - 22q11.2 microdeletion syndrome and 3q29 microdeletion syndrome. The research will focus on disruptions in thalamocortical projections between the auditory thalamus and auditory...
- This Project Grant award of $201,250 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA Program 93.173 "Research Related to Deafness and Communication Disorders" supports research to examine precursors to language impairment in autism spectrum disorder (ASD). The project aims to leverage recent advances in remote assessment of infant cognitive development to test three proposed mechanisms underlying language impairment in ASD: atypical speech...
This $461,375 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research by Yale University to characterize the dynamic neural indices of sound sensitivity in autism. The project aims to investigate how the neural circuit that adjusts auditory perception and arousal differs in individuals with autism compared to those without, in order to better understand the mechanisms underlying auditory sensory experiences in autism. The researchers will measure brain activity and pupil diameter while participants with and without autism listen to sounds of varying intensity, using novel analytical techniques to quantify the strength of associations between neural responses, sound intensity, and arousal. This research seeks to identify consistent neural markers of atypical auditory sensitivity in autism, which could inform the development of more effective treatments and assessment methods. The award period runs from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $461.4k | 8/20/25 |