Project Grant R21MH138988
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the Regents of the University of Michigan a $3.97 million Project Grant (CFDA 93.242 - Mental Health Research Grants) effective August 1, 2025, through July 31, 2028, to develop a scalable high-plex pipeline for whole-brain proteomics profiling. The project addresses a critical gap in neuroscience research by creating a comprehensive proteomics atlas of the mammalian brain, complementing existing transcriptomics...
- Federal Grant Award Summary Michigan State University's Henry Ford Health+Michigan State University Health Sciences partnership received a $878,991 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 10, 2025, with a completion date of August 31, 2030. The award supports development of genetically encoded Input/Output (I/O) Tags—designer proteins that enable targeted trans-neuronal...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $2.9 million to the Regents of the University of Michigan under the Mental Health Research Grants program (CFDA 93.242) on September 22, 2025, for a four-year project period extending through September 21, 2029. This Project Grant supports basic neuroscience research investigating the neural mechanisms underlying associative learning, with a focus on identifying how midbrain signals contribute to differential...
- Federal Grant Award Summary Michigan State University received a $416,859 Project Grant from the National Institute of Mental Health under the Mental Health Research Grants program (CFDA 93.242) awarded on March 3, 2026, with a completion date of February 29, 2028. This exploratory R21 research initiative investigates nucleolar dysfunction as a novel pathological mechanism in Fragile X Syndrome (FXS), a leading genetic cause of intellectual disability and autism spectrum disorders. The...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $1.45M Project Grant under the Mental Health Research Grants program (CFDA 93.242) on April 15, 2025, to develop an engineered bioprinting platform for studying neural migration in brain assembloids. The project, scheduled for completion by February 28, 2030, will deliver a novel magnetic three-dimensional bioprinting technology termed SPOT to enhance the quality,...
- Federal Grant Award Summary The Scripps Research Institute received a $878,601 Project Grant award from the National Institute of Mental Health under the Mental Health Research Grants program (CFDA 93.242), effective April 1, 2026, with completion targeted for December 31, 2030. This collaborative research program delivers advanced neuroscience research services focused on understanding how neural circuits in the mammalian brain reorganize to encode new memories. The project combines...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $431,750 to Henry Ford Health + Michigan State University Health Sciences on May 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The project, scheduled for completion by April 30, 2027, develops an innovative positron emission tomography (PET)-based molecular neuroimaging technique to map neural circuits involved in...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $429,000 Project Grant to the Regents of the University of Michigan on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This two-year award, with an ultimate completion date of July 31, 2027, funds research to identify the mechanism of Notch pathway inhibition resistance in glioblastoma (GBM) stem cells. The...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $431,750 Project Grant on July 23, 2025, to Michigan State University (through Henry Ford Health + Michigan State University Health Sciences) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research project will develop and implement translational neuroscience methodologies to examine neurobiological mechanisms underlying heterogeneity...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $150,104 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective December 30, 2025, with completion targeted for June 30, 2028. The grant supports basic neuroscience research investigating intracellular signaling mechanisms that dynamically control synaptic responses in the basal ganglia, specifically focusing on the...
Michigan State University (through its partnership with Henry Ford Health+Michigan State University Health Sciences) received a $431,750 Project Grant from the National Institute of Mental Health under the Mental Health Research Grants program (CFDA 93.242) to develop transgenic tools and methodologies for accessing semilunar granule cells (SLGCs) in the dentate gyrus of the mouse brain in vivo. The two-year project, awarded March 10, 2026 and concluding March 9, 2028, will generate experimental tools and biological knowledge products that enable future research into how SLGCs regulate granule cell activity and contribute to hippocampal function. This research addresses a critical gap in neuroscience by providing researchers with genetic access to an understudied cell type, thereby supporting broader investigations into the neurobiological mechanisms underlying cognition, behavior, and mental health disorders. The project delivers two primary research products: (1) optimized strategies for recombinase expression in SLGCs through tamoxifen-inducible Cre and complementary approaches (Aim 1), and (2) empirical validation of the hypothesis that SLGCs functionally constrain granule cell activity through in vivo experimental testing (Aim 2). These deliverables will advance the understanding of dentate gyrus circuitry and potentially inform treatment approaches for hippocampal-dependent cognitive disorders and seizure-related pathologies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 3/9/26 |