This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $251,250 to The Feinstein Institutes for Medical Research to study sex-dependent dysregulation of parvalbumin interneurons as a pathway to autism spectrum disorder (ASD). The research aims to examine whether in utero exposure to anti-CASPR2 antibodies has sex-specific epigenetic effects on the maturation of parvalbumin interneurons, which may contribute to neural network imbalances in male mice. Key activities include investigating epigenetic changes disrupting the transcriptional profile of parvalbumin interneurons, and characterizing the development of abnormal parvalbumin interneuron network patterns and their functional consequences. This work leverages the Feinstein Institutes' expertise in neuroscience, immunology, and translational research to advance the understanding of ASD pathophysiology. The award period runs from September 2024 through August 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $251.3k | 9/23/24 |