The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), was awarded a $459,250 federal Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The 2-year grant, running from August 15, 2023 to August 14, 2025, will fund research to investigate the state-dependent effects of transcranial alternating current stimulation (TACS) on theta-gamma cross-frequency coupling and fronto-parietal phase synchronization, which are critical to working memory function.
Specifically, the project aims to test whether TACS with theta-nested gamma waveforms delivered during key task epochs will improve these neural markers of working memory, compared to TACS during task-free periods or sham stimulation. The researchers will also assess whether closed-loop gamma TACS synchronized with ongoing theta oscillations can enhance these neural measures more than open-loop TACS. The findings are expected to identify strategies for manipulating theta-gamma interactions and fronto-parietal synchronization to support working memory and lay the groundwork for potential clinical trials in relevant patient populations.
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