Project Grant R21MD020875
- The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $776,863 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Michigan. The grant supports multi-ancestry whole genome sequencing analyses and functional follow-up studies of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a prevalent and growing liver disease globally. The research aims to...
- This federal Project Grant award for $824,655.00, awarded on July 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the molecular and regulatory mechanisms by which growth hormone (GH) and the transcription factor STAT5 protect the liver from metabolic dysfunction-associated steatotic liver disease (MASLD). The research aims to...
- This Project Grant award of $544,963 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research by Emory University to investigate the role of frataxin (FXN) in liver injury related to metabolic dysfunction-associated steatotic liver disease (MASLD). The research aims to determine whether FXN deficiency induces ferroptosis-mediated liver injury in MASLD and if restoring FXN expression...
- This $441,375 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research on the transcriptional mechanisms underlying chronic inflammation in genetically diverse liver macrophages (Kupffer cells) during metabolic dysfunction-associated steatotic liver disease (MASLD). The research aims to understand how genetic variation in regulatory regions controls gene expression in Kupffer cells, which play a...
- This federal Project Grant award of $786,216.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research on the post-transcriptional regulation of hepatokines and their role in systemic metabolism. The research, conducted by the University of California, Los Angeles (UCLA), aims to elucidate a novel mechanism by which the liver controls metabolic homeostasis...
- This $1,778,953 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research to investigate the relationship between HIV persistence, chronic immune activation, and metabolic complications in people living with HIV. The primary objectives are to explore the natural history of metabolic dysfunction in the context of persistent HIV reservoirs and chronic inflammation,...
- The University of Mississippi Medical Center (UMMC) was awarded a $604,818 Project Grant by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) with a project period from May 15, 2025 to February 28, 2029. The grant supports research to investigate the role of non-alcoholic fatty liver disease (NAFLD), also known as metabolic dysfunction-associated steatotic liver disease (MASLD), in the development of cardiovascular disease....
- This $348,530 Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) supports a collaborative research project between Howard University and North Carolina A&T State University (NC A&T) to identify the dynamic structure of Type 2 diabetes progression. The project aims to develop mathematical models that can reveal the threshold behavior and personalized dynamics of diabetes onset, with the goal of informing new treatment methods. Key...
- The National Institute on Minority Health and Health Disparities (NIMHD) awarded a $764,143 Project Grant under the Minority Health and Health Disparities Research program (CFDA 93.307) to the Sloan-Kettering Institute for Cancer Research in New York. The grant, titled "FAMILY COMIDA (CONSUMO DE OPCIONES MAS IDEALES DE ALIMENTOS) (EATING MORE IDEAL FOOD OPTIONS)", aims to address the obesity epidemic among the Hispanic population, a community at increased risk for obesity and...
- This $2,651,504 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to identify the mechanisms by which impairments in long chain fatty acid oxidation, specifically through deletion of the CPT1A enzyme, influence the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). The research...
This Project Grant award from the National Institute on Minority Health and Health Disparities (CFDA 93.307 - Minority Health and Health Disparities Research) provides $424,875 to Howard University to conduct research on the pathobiology of metabolic dysfunction-associated steatotic liver disease (MASLD) in the African American (AA) population with type 2 diabetes mellitus (T2DM). The project aims to comprehensively characterize the transcriptomic signatures and molecular pathways related to inflammation, insulin resistance, and fibrosis that contribute to the progression of hepatic steatosis in AAs with T2DM. This exploratory research is intended to improve understanding of the underlying disease mechanisms and lower incidence of MASLD in the AA population despite high prevalence of metabolic risk factors. The award period is from September 19, 2025 to June 30, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $424.9k | 9/19/25 |