Project Grant R21HL184309
- The National Heart, Lung, and Blood Institute awarded Northwestern University $440,000 on September 1, 2026, under CFDA 93.837 (Cardiovascular Diseases Research) for the SPARTACUS project, a two-year effort to develop and validate an artificial intelligence tool that predicts stroke risk in atrial fibrillation patients taking anticoagulant medications. Northwestern will develop an advanced AI system called MIST-MAMBA that processes multiple data types—cardiac ultrasound, heart rhythm recordings,...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $684,570 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate a bioengineered mitochondrial therapy platform for endothelial repair in vascular surgery. The research addresses endothelial injury, a fundamental barrier in vascular procedures that contributes to post-operative complications including vein graft failure, restenosis, and thrombosis. Northwestern's...
- The National Heart Lung and Blood Institute awarded the Regents of the University of Michigan $567,166 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop tunable multi-thrombolytic nanoformulations for treating ischemic stroke with minimal hemorrhagic risk. The research addresses limitations of current thrombolytic therapy—tissue plasminogen activator (tPA) carries serious intracranial hemorrhage complications, while plasmin, a more effective...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $2,162,045 under Cardiovascular Diseases Research (CFDA 93.837) on September 15, 2025, for research characterizing apolipoprotein proteoforms and their relationships with cardiometabolic health and coronary heart disease events. The research objective is to characterize the full spectrum of apolipoprotein post-translational modifications in human plasma and to quantify their associations with adiposity, insulin...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $696,259 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop flexible electronics and optogenetics approaches for real-time arrhythmic profiling of engineered heart tissues. The project runs through April 30, 2031, with work performed in Chicago, Illinois. The award funds development of non-invasive arrhythmia assessment methods for human induced pluripotent stem cell–derived...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $1,597,024 under the Cardiovascular Diseases Research program (CFDA 93.837) on July 1, 2026, to investigate mitochondrial quality control mechanisms in donor heart endothelial and smooth muscle cells as a strategy to improve cardiac allograft survival and reduce cardiac allograft vasculopathy following heart transplantation. The research addresses the acute and chronic phases of transplant injury:...
- The National Heart Lung and Blood Institute awarded Northwestern University $654,762 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate regulatory T cell mechanisms limiting persistent inflammation during recovery from viral pneumonia. The award funds research into how FOXP3+ regulatory T cells orchestrate lung repair after viral pneumonia through expression of suppressive mediators, particularly the anti-inflammatory cytokine interleukin-10. The...
- The National Heart, Lung, and Blood Institute awarded the University of Illinois $109,076 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop individualized prediction methods for heart failure progression using digital twins and explainable reinforcement learning. The project will characterize cardiac performance at the individual level using primary echocardiographic images, quantitative echocardiographic measures, and arterial pulse wave velocity...
- The National Heart, Lung, and Blood Institute awarded Northwestern University a project grant of $793,976 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate bone morphogenetic protein and connexin40 signaling as regulators of endothelial quiescence in lung transplantation. The research addresses primary graft dysfunction, an acute lung injury driven by ischemia-reperfusion injury that limits lung transplantation success. The project will...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $1,589,058 under the Cardiovascular Diseases Research program (CFDA 93.837) on June 25, 2026, to support research on disordered mitochondrial proteostasis and alveolar epithelial repair in aging lungs. The project investigates how age-related dysfunction in mitochondrial complex I impairs lung recovery following viral pneumonia, with a focus on the role of alveolar epithelial type 2 cells in epithelial repair and the...
The National Heart, Lung, and Blood Institute awarded Northwestern University $120,000 on July 21, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) for Project Grant R21HL184309. The award funds development of probabilistic and explainable machine learning methods to predict technical success and stroke outcomes following mechanical thrombectomy for acute ischemic stroke patients with large vessel occlusion. Northwestern will develop state-of-the-art probabilistic models that infer outcome distributions rather than singular outcome estimates, leveraging data from the Neurovascular Quality Initiative – Quality Outcomes Database, which contains clinical, procedural, and outcomes information for over 10,000 mechanical thrombectomy procedures. This probabilistic approach is designed to provide clinicians with more informative prognostic assessments that reflect real-world clinical uncertainty in patient outcomes. Work is performed in Chicago, Illinois, with a period of performance through May 31, 2028. The award is assistance in the form of a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $120.0k | 7/22/26 |