Project Grant R21HL181673
- This federal Project Grant award of $727,080 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the neurogenic mechanisms underlying psychosocial stress-induced cardiovascular disease and postpartum depression. The primary research objective is to delineate how stress-evoked mitochondrial dysfunction in the medial prefrontal cortex contributes to postpartum cardiovascular and behavioral changes. The 4-year project,...
- This federal Project Grant award of $163,145.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate sex differences in cardiac macrophages and their role in right ventricular function in pulmonary arterial hypertension (PAH). The University of Colorado-Denver, the awardee, will conduct this research with the goal of understanding how female sex hormones regulate gene expression in right ventricular macrophages and...
- The federal Project Grant award of $117,525.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is funding research at Boston Children's Hospital to investigate cellular adaptation to perturbations in one-carbon metabolism. The research aims to characterize the role of the UFMylation pathway in maintaining cellular fitness during folate depletion, and explore signaling cascades that promote cellular fitness in response to one-carbon metabolism...
- The National Heart, Lung, and Blood Institute awarded a $156,486 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Denver. The 5-year grant, running from July 2, 2025 to January 5, 2027, will support research examining the association between discrimination reported during pregnancy and cardiovascular disease risk in mothers 3-4 years postpartum. The study will use a prospective longitudinal design with a population of at least 200...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $777,954 to the Icahn School of Medicine at Mount Sinai to conduct research on improving preconception cardiovascular health among adolescents. The key products and services to be delivered through this grant include: Constructing a school-based adolescent preconception cohort through data linkages to study the influence of school environments on cardiovascular risk...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support a study examining the link between stressful life events and cardiovascular disease (CVD) risk. The $156,858 award, granted on February 1, 2025, will enable the University of Pittsburgh to utilize deidentified data from 656 healthy adults to investigate how brain and behavioral measures of negative affect and cognitive reappraisal...
- This federal Project Grant award for $696,470, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the relationship between prenatal maternal sleep and cardiovascular disease risk in offspring. The University of Denver is the primary awardee, and they have sub-awards with Northwestern University and the University of Colorado, Anschutz Medical Center. The key objectives are to: 1) examine how prenatal maternal sleep...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $422,894 to support research examining the interactive effects of cardiorespiratory fitness and adiposity on the recovery of impaired glucose and vascular control following a period of physical inactivity. The award period is from April 20, 2025 to March 31, 2028. The key objectives of the project are to: 1) investigate how existing health status...
- This $691,124.00 project grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on the relationship between circadian disruption and cardiometabolic risk during the transition from adolescence to young adulthood. The project aims to test the hypothesis that persistent circadian disruption, including misaligned sleep, eating, and activity timing, will be related to the development of cardiometabolic risk through epigenetic...
- The National Heart, Lung, and Blood Institute awarded a $133,125 project grant to Northwestern University under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the relationship between early life social determinants of health, epigenetic changes, and young adult blood pressure levels. The overarching goal is to identify potential epigenetic mechanisms that mediate the association between social determinants and the development of hypertension, a key risk factor for...
This $275,196 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Chicago investigating the impact of adolescent reproductive health factors on the risk of cardiometabolic disease in young adult women. The project aims to analyze longitudinal data from the Pittsburgh Girls Study to examine associations between adolescent pubertal development, sexual health, and pregnancy history with biomarkers of cardiometabolic health in early adulthood (ages 21-24). The research will also explore how patterns of stress exposure during adolescence may moderate these relationships. The findings are intended to inform preventive interventions addressing the observed sex differences in cardiometabolic disease risk. The project period runs from September 2025 to August 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $275.2k | 9/23/25 |