Project Grant R21HL181649
- This $292,500 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to identify novel microproteins associated with normal hematopoiesis and hematopoietic diseases. The project will leverage existing transcriptomic and translation data to produce a comprehensive catalog of microproteins expressed in different hematopoietic cell types. This inter-disciplinary research conducted by the Sanford Burnham Prebys Medical Discovery...
- This federal Project Grant award of $552,413.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to Thomas Jefferson University's Sidney Kimmel Medical College. The grant will support research over a period of 4 years, from April 1, 2025 to January 31, 2029, with the goal of investigating siRNA-mediated in vivo knockdown of key regulators of platelet and megakaryocyte function, including the P2Y12 receptor,...
- The University of Rochester was awarded a $573,261 Project Grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to investigate the role of platelets in regulating monocyte immune responses during vascular inflammation. The 4-year research project, beginning August 1, 2025, aims to understand how resting platelets interact with monocytes to epigenetically "train" their innate immune responses, and how this process is altered by platelet...
- This $240,552 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a research project titled "Unraveling the Cell Networks in Bone Marrow Through Transcriptomic and Epigenetic Profiling" at the University of Pennsylvania. The project aims to generate a comprehensive single-cell transcriptomic and regulomic map of human bone marrow cells and experimentally establish the mesenchymal cell hierarchy in human bone....
- This Project Grant award for $713,538 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate metabolic reprogramming as a novel therapeutic approach for thrombotic cardiovascular disease. The key objectives are to explore how inhibiting the cytosolic malic enzyme 1 (ME1) in platelets and leukocytes can reduce their hyperactivation and susceptibility to arterial thrombosis, while minimizing bleeding risk compared to...
- This federal Project Grant award of $1,119,410.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a multi-disciplinary research initiative to investigate longitudinal changes in DNA methylation (LC-DNAM) and its relationship to cardiovascular disease (CVD) risk factors and outcomes across four large population-based cohort studies - ARIC, CARDIA, FHS, and MESA. The research aims to: 1)...
- This $604,301 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Versiti Wisconsin, Inc. will support research on membrane-cytoskeleton interactions in megakaryocytes and platelets. The research aims to advance the understanding of abnormal platelet production and function, which can pose significant clinical risks including bleeding and thrombotic events. The project will investigate the precise molecular mechanisms...
- The National Heart Lung and Blood Institute, through the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $249,000 project grant to Rutgers, The State University of New Jersey. The grant is focused on identifying novel epigenetic regulators of lymphocyte (T cell) development, with the goal of facilitating the generation of robust induced pluripotent stem cell (iPSC)-derived T cells for adoptive cell immunotherapy. The project aims to perform small molecule...
- This federal Project Grant award, totaling $753,813 and provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research to develop novel machine learning techniques for predicting cardiovascular outcomes in patients with clonal hematopoiesis of indeterminate potential (CHIP). The key goals are to use cardiac MRI imaging and genomic data to: 1) Develop a machine learning model to accurately identify CHIP patients and predict their risk...
- This Project Grant award for $445,000.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The funding supports research conducted by The Children's Hospital of Philadelphia (CHOP) to study the role of neutrophil extracellular traps (NETs) in inflammatory and thrombotic diseases. The project aims to characterize the role of NETs in immune homeostasis, determine the mechanisms by which NET stabilization...
This federal Project Grant award of $235,500.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance precision medicine across a range of disease areas, including cardiovascular, immune-mediated, cancer, and hematologic diseases. The key objectives are to: Leverage advanced machine learning and bioinformatics tools to analyze platelet transcriptomic profiles across these diverse disease categories, in order to uncover common and unique molecular pathways that could serve as shared biomarkers or therapeutic targets. Construct a comprehensive, functionally annotated multi-disease platelet transcriptomic atlas, analyzing gene expression patterns, isoforms, alternative splicing, and other platelet-specific molecular features. The project will utilize curated RNA-sequencing datasets from over 2,000 individuals to achieve these goals, with the ultimate aim of informing biomarker discovery and universal therapeutic strategies for NHLBI-relevant diseases. The award was granted to Rutgers, The State University, located in New Jersey, and has a performance period from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $235.5k | 8/28/25 |