Project Grant R21HL181646
- This federal Project Grant award, with a total funding amount of $304,415.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The goal of this 1-year project is to develop a software solution that uses artificial intelligence and image analytics to improve cardiovascular risk prediction from screening CT calcium score (CTCS) images. The project team, which includes engineers and clinicians from...
- This Project Grant award of $116,250 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support research at The Johns Hopkins University to study the prevalence, risk factors, and progression of calcific aortic valve disease (CAVD) and severe aortic stenosis in persons over 75 years old. The research aims to: 1) identify long-term risk factors for the development of aortic valve calcification, 2) create population percentiles for aortic valve...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $224,142 to conduct an epidemiologic study on the prevalence and correlates of atherosclerotic resilience among 4,000 participants in the NHLBI-funded RURAL cohort study across the Southeastern U.S. The study aims to determine the prevalence of coronary artery calcium (CAC) scores of zero, a marker of atherosclerotic resilience, according to age, sex, and race in...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $756,906 to Mayo Clinic to conduct a population-based study on using deep learning methods to detect and quantify breast arterial calcification (BAC) from mammogram images. The study aims to leverage the high rates of mammography screening to explore BAC as a biomarker for predicting cardiovascular disease risk in women. The project will analyze data from 125,519...
- This Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The $138,523 award to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System) will fund research to investigate the distinct mechanisms underlying medial and intimal calcification in blood vessels, which are associated with increased cardiovascular disease risk. The research aims to systematically...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $774,229 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to Kaiser Foundation Hospitals to conduct a large longitudinal cohort study on cardiometabolic outcomes among adolescents and young adults (AYA). The goal is to better understand the epidemiology of cardiometabolic conditions like hypertension, prediabetes, and fatty liver disease in AYA populations, identify high-risk groups, and inform early...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $742,395 to Case Western Reserve University (CWRU) to develop and validate a machine learning-based analysis of coronary artery calcium scans (CTCS) to identify biomarkers for predicting heart failure risk. The 4-year project aims to create an automated tool for extracting CTCS-derived radiomics, develop a comprehensive heart failure risk...
- The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $126,309 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Children's Hospital Medical Center in Cincinnati, Ohio. This 2-year research project, awarded on June 16, 2025, aims to characterize the functional role of a novel cardiac and adipose-enriched microprotein called NRAC and its involvement in lipid droplet biogenesis and lipid metabolism within the cardiovascular system. The research will...
- This $722,299 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a research initiative to use deep learning techniques to study normal variation in aortic valve hemodynamics and its link to the development of aortic stenosis. The primary objectives are to: 1) Measure aortic valve parameters in 100,000 UK Biobank participants using deep learning models, validate the measurements at UCSF, and develop models to identify...
- The federal Cooperative Agreement award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, with a total funding amount of $952,993.00 and a performance period from July 30, 2025 to June 30, 2032, will support a clinical study entitled "PREEMPT: Prospective Randomized Evaluation and Management of Premature Atherosclerosis." The study aims to develop optimal strategies for screening,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $232,500 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Johns Hopkins University to conduct a 30-year follow-up study of the Coronary Artery Calcium Consortium (CAC Consortium). The goal of the project is to quantify long-term survival and cardiovascular mortality risk prediction for individuals aged 30-59 based on their baseline coronary artery calcium (CAC) scores. The research aims to evaluate the prognostic value of CAC scanning over a 30-year time horizon, which is critical for improving 30-year risk estimation in young to middle-aged adults. The project will leverage the existing CAC Consortium cohort to provide survival data on approximately 5,000 patients aged 30-59 and 30,000 patients with at least 25-year follow-up, enabling robust analyses on the implications of CAC scoring for long-term cardiovascular health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $232.5k | 8/26/25 |