Project Grant R21HL181440
- This federal Project Grant award for $726,035.00 was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to map the vagal and spinal afferent innervation of healthy and diabetic rat hearts, as well as adapt these techniques to study diabetes-induced remodeling of nociceptive afferent innervation in human hearts. The primary objectives are to better understand the structural and functional roles of these cardiac afferent nerves, including...
- This $117,000 Project Grant award from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) supports secondary analysis of 3D echocardiographic (echo) images of the right ventricle (RV) to compute 3D surface strain. The goal is to develop enhanced 3D strain analysis techniques that can provide more detailed characterization of RV deformation compared to standard 2D global longitudinal strain (GLS) measures, with the potential to improve...
- The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) was awarded a $774,997 project grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on the contribution of medullary pre-sympathetic neurons to the progression of breathing disorders and autonomic dysfunction in heart failure with preserved ejection fraction (HFPEF). The project aims to provide in-vivo and in-vitro neuronal activity mapping of the...
- The University of Colorado-Denver received a $553,217 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) on August 15, 2025. The grant supports research on the "HAT-Dependent Control of Cardiac Fibrosis" to investigate the role of epigenetic regulatory proteins in controlling the activation of cardiac fibroblasts and development of cardiac fibrosis, which contributes to diastolic dysfunction and heart failure. The...
- The National Heart, Lung, and Blood Institute (NHLBI), through the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $234,000 Project Grant to the University of Colorado-Denver. This 2-year grant, effective August 1, 2025 through July 31, 2027, will support secondary analysis of noninvasive imaging biomarkers to predict the early onset of single ventricle heart disease (SVD) failure. The research aims to quantify systemic and pulmonary vascular compliance through...
- This federal Project Grant award for $569,695.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research into the therapeutic potential of phrenic proprioceptors, or sensory neurons, to restore respiratory function after cervical spinal cord injury. The research, conducted by Marquette University, aims to test the hypothesis that activating these phrenic proprioceptors can induce spinal plasticity and improve breathing...
- This $472,511 Project Grant award from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research on the neural mechanisms underlying premature ventricular contraction (PVC)-induced cardiomyopathy. The primary awardee, Richmond Institute for Veterans Research (also doing business as McGuire Research Institute Inc.), will investigate how PVCs lead to neural remodeling that promotes cardiac remodeling and arrhythmias. The...
- This $298,368 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a novel device for treating mitral valve regurgitation. The project aims to optimize the device design and procedure through bench testing, followed by acute in vivo studies to demonstrate the feasibility of the approach. The funding recipient, Link Medical LLC, has invented a catheter-based technology intended to restore proper mitral...
- The U.S. National Heart, Lung, and Blood Institute, through the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $406,221 Project Grant to the Florida Institute of Technology Inc. (Florida TECH) on September 15, 2025. The grant supports the development of a novel, low-cost, machine learning-based and wearable technology for continuous monitoring of heart failure parameters, such as left ventricular function. The project aims to address the gap in remote cardiac...
- The University of Florida received a $149,348 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the cellular mechanisms of acute-intermittent hypercapnic-hypoxia induced phrenic motor plasticity. The project will monitor phrenic nerve activity in anesthetized rats as a proxy for respiratory motor output, with the goal of enhancing understanding of the pathways involved in phrenic long-term facilitation (PLTF)...
This federal Project Grant award of $429,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund a study to investigate the impact of selective vagal neuromodulation on heart failure indices. The 2-year project, with a start date of September 1, 2025, will be conducted by the University of Colorado-Denver. The research aims to better understand the neural interface by studying the effects of selective activation of cholinergic (efferent) and glutamatergic (afferent) neuronal subsets of the vagus nerve on left ventricular structure, function, and inflammatory markers in a rodent heart failure model. Leveraging optical neuromodulation and 3D-printed nerve cuffs, the study seeks to inform stimulation strategies for potential future clinical applications to improve outcomes for heart failure patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 8/28/25 |