Project Grant R21HL181073
- This $2,024,340 Project Grant was awarded on August 15, 2025 by the National Heart Lung and Blood Institute (NHLBI), part of the National Institutes of Health, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports a multi-year research effort at Boston Children's Hospital to optimize outcomes for hematopoietic stem cell transplantation (HCT), an essential treatment for high-risk non-malignant and malignant hematologic diseases. The research project...
- This Project Grant award, valued at $465,000.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The funding supports research to investigate the mechanisms by which chronic inflammation disrupts the hemostatic balance in sickle cell disease (SCD). Specifically, the project aims to understand how tumor necrosis factor-alpha (TNFa) induced inflammation blocks autophagy and mitophagy in platelets and...
- This Project Grant award of $125,532.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the disruption of the clonal architecture of human hematopoietic stem cells driven by high-effect somatic and germline genetic variants, and identify the resulting phenotypic changes that lead to impaired stem cell function and increased disease risk with aging. The research will utilize a mitochondrial lineage tracing...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $166,644 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Trustees of Columbia University in the City of New York on July 16, 2025. This 5-year grant will support research examining how aging and TET2 mutations affect the inflammatory response of human hematopoietic stem cells. The research aims to improve understanding of how these factors contribute to the development of blood disorders like...
- This $109,812 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on using extracellular vesicles derived from endothelial cells to potentially treat vascular disease in MELAS, a common mitochondrial disorder. The research aims to characterize the mitochondrial content and quality within these extracellular vesicles and assess their ability to ameliorate inflammatory effects in MELAS-affected endothelial cells....
- This federal Project Grant award of $1,119,410.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a multi-disciplinary research initiative to investigate longitudinal changes in DNA methylation (LC-DNAM) and its relationship to cardiovascular disease (CVD) risk factors and outcomes across four large population-based cohort studies - ARIC, CARDIA, FHS, and MESA. The research aims to: 1)...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,276,908 in funding to Bloodworks, a non-profit organization based in Seattle, Washington. The award, effective March 1, 2025 through February 28, 2032, supports molecular and translational research studies focused on hematological disorders, specifically von Willebrand disease and sickle cell disease. The research aims to...
- This $147,486.00 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of high-fat diet in hematopoiesis (blood cell formation) and clonal hematopoiesis, a condition associated with increased risk of myeloid diseases like myelodysplastic syndrome and acute myeloid leukemia. The award was made to the Regents of the University of Michigan, Ann Arbor for a project period running from Jul 9,...
- This Project Grant award, provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research on the use of donor-derived cell-free DNA for risk stratification and post-treatment monitoring of lung transplant patients at risk of chronic lung allograft dysfunction. The award, totaling $248,999.00, will be provided to the University of Maryland, Baltimore to fund this 3-year research project from July 2025 to May 2028. The project aims to...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,123,357.00 to support research on the bone marrow microenvironment and its role in regulating blood cell production. The research, to be conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, aims to define the spatial organization and specialized vascular microenvironments within the bone marrow that recruit and...
This $262,500 Project Grant was awarded on September 15, 2025 by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research by the Vitalant Research Institute to define the drivers of mitochondrial DNA (mtDNA) levels in blood components and their impact on transfusion-related lung injury. The research aims to explore the recently discovered link between the ANKLE1 gene and mtDNA levels in blood donor products, with implications for enhancing transfusion safety through precision medicine approaches. Key activities include optimizing assays to quantify ANKLE1 protein expression and mtDNA levels across different blood sample types. The research could identify a potential druggable target to affect mtDNA in blood products and further the understanding of non-infectious transfusion risks.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $262.5k | 9/9/25 |